(S)-1-N-BENZYL-2-CYANO-PYRROLIDINE

Base Information

• Chemical Name: (S)-1-N-BENZYL-2-CYANO-PYRROLIDINE
• CAS No.: 928056-25-1
• Molecular Formula: C12H14 N2
• Molecular Weight: 186.257
• Hs Code.: 2933990090
• Mol file: 928056-25-1.mol

Synonyms:(s)-1-benzyl-pyrrolidine-2-carbnitrile;1-benzyl-pyrrolidine-2-carbonitrile;(S)-1-benzylpyrrolidine-2-carbonitrile;(s)-1-n-benzyl-2-cyano-pyrrolidine;

Chemical Property of (S)-1-N-BENZYL-2-CYANO-PYRROLIDINE

Chemical Property:

• Vapor Pressure: 0.0005mmHg at 25°C
• Boiling Point: 313.3°C at 760 mmHg
• Flash Point: 132.8°C
• PSA: 27.03000
• Density: 1.08g/cm³
• LogP: 2.11248

Purity/Quality:

97% ^*data from raw suppliers

(S)-1-N-Benzyl-2-cyanopyrrolidine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-1-N-BENZYL-2-CYANO-PYRROLIDINE

There total 2 articles about (S)-1-N-BENZYL-2-CYANO-PYRROLIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(S)-1-benzyl-pyrrolidine-2-carboxylic acid amide (114883-85-1) → 1-benzyl-pyrrolidine-2-carbonitrile (928056-25-1)

Guidance literature:

With diisopropylamine; trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 0.666667h;

DOI:10.1021/jo062221e

Reference yield:

N-benzyl-L-proline (31795-93-4) → 1-benzyl-pyrrolidine-2-carbonitrile (928056-25-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / (NH₄)2CO₃; Boc₂O; pyridine / dioxane

2: 66 percent / trifluoroacetic anhydride; diisopropylamine / CH₂Cl₂ / 0.67 h / 20 °C

With pyridine; di-tert-butyl dicarbonate; ammonium carbonate; diisopropylamine; trifluoroacetic anhydride; In 1,4-dioxane; dichloromethane;

DOI:10.1021/jo062221e

Reference yield: 93.0%

1-benzyl-pyrrolidine-2-carbonitrile (928056-25-1) + methyl trifluoromethanesulfonate (333-27-7) → 1-benzyl-2-cyano-1-methyl-pyrrolidinium trifluoromethanesulfonate

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jo062221e

upstream raw materials:

(S)-1-benzyl-pyrrolidine-2-carboxylic acid amide

N-benzyl-L-proline