[(3R)-1-benzylpyrrolidin-3-yl]methanamine

Base Information

• Chemical Name: [(3R)-1-benzylpyrrolidin-3-yl]methanamine
• CAS No.: 229323-04-0
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.288
• DSSTox Substance ID: DTXSID80364036
• Mol file: 229323-04-0.mol

Synonyms:229323-04-0;[(3R)-1-benzylpyrrolidin-3-yl]methanamine;(R)-(1-benzylpyrrolidin-3-yl)methanamine;MFCD09607977;3-Pyrrolidinemethanamine, 1-(phenylmethyl)-, (3R)-;(1-Benzylpyrrolidin-3-yl)methylamine;SCHEMBL3074896;DTXSID80364036;AKOS017344510;TS-02687;(R)-(1-Benzylpyrrolidin-3-yl)methylamine;1-[(3R)-1-Benzylpyrrolidin-3-yl]methanamine;(R) -C-(1-Benzyl-pyrrolidin-3-yl)-methylamine;3-Pyrrolidinemethanamine,1-(phenylmethyl)-,(3R)-

Chemical Property of [(3R)-1-benzylpyrrolidin-3-yl]methanamine

Chemical Property:

• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.563
• Boiling Point: 284.3 °C at 760 mmHg
• Flash Point: 115.3 °C
• PSA: 29.26000
• Density: 1.04 g/cm³
• LogP: 2.10540
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 190.146998583
• Heavy Atom Count: 14
• Complexity: 164

Purity/Quality:

99% ^*data from raw suppliers

(3R)-3-AMINOMETHYL-1-BENZYLPYRROLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1CN(CC1CN)CC2=CC=CC=C2
• Isomeric SMILES: C1CN(C[C@H]1CN)CC2=CC=CC=C2

Technology Process of [(3R)-1-benzylpyrrolidin-3-yl]methanamine

There total 1 articles about [(3R)-1-benzylpyrrolidin-3-yl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-benzylpyrrolidine-3-carbonitrile (159063-16-8) → ((R)-1-benzyl-pyrrolidin-3-yl)-methyl-amine (229323-04-0)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 2h;

DOI:10.1016/S0960-894X(99)00086-4

Reference yield:

4-amino-5-chloro-2-methoxybenzoic acid (7206-70-4) + ((R)-1-benzyl-pyrrolidin-3-yl)-methyl-amine (229323-04-0) → 4-amino-N-(1-benzyl-pyrrolidin-3-ylmethyl)-5-chloro-2-methoxy-benzamide

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; 1.) 16 h, RT, 2.) 0 deg C, 24 h;

DOI:10.1016/S0960-894X(99)00086-4

Reference yield:

4-(acetylamino)-5-chloro-2-methoxybenzoic acid (24201-13-6) + ((R)-1-benzyl-pyrrolidin-3-yl)-methyl-amine (229323-04-0) → 4-acetylamino-N-(1-benzyl-pyrrolidin-3-ylmethyl)-5-chloro-2-methoxy-benzamide

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethyl acetate; 1.) 16 h, RT, 2.) 0 deg C, 24 h;

DOI:10.1016/S0960-894X(99)00086-4

upstream raw materials:

(S)-1-benzylpyrrolidine-3-carbonitrile