159063-16-8

Usage

Uses

Used in Pharmaceutical Industry:
(S)-1-Benzyl-pyrrolidine-3-carbonitrile is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs and medications, particularly those aimed at treating central nervous system disorders.
Used in Chemical Industry:
In the chemical industry, (S)-1-Benzyl-pyrrolidine-3-carbonitrile serves as a building block for the creation of other organic compounds. Its versatility in chemical reactions makes it a valuable component in the synthesis of a wide range of products.
Used in Materials Science:
(S)-1-Benzyl-pyrrolidine-3-carbonitrile is also being studied for its potential applications in materials science. Its unique properties may contribute to the development of new materials with specific characteristics, further expanding its utility in various fields.
Used in Organic Chemistry:
(S)-1-BENZYL-PYRROLIDINE-3-CARBONITRILE's structure and reactivity make it a valuable asset in organic chemistry, where it can be used to explore new reaction pathways and develop innovative synthetic methods.

Upstream product

• 100-52-7 benzaldehyde 
• 101385-90-4 (R)-N-benzyl-3-hydroxypyrrolidine 
• 159497-65-1 N,N-dibenzylasparaginic acid dibenzyl ester 
• 137428-32-1 (2S)-2-[bis(phenylmethyl)amino]-1,4-butanediol 
• 143-33-9 sodium cyanide 
• 114715-35-4 (R)-3-methanesulfonyloxy-1-(phenylmethyl)-pyrrolidine 
• 2408-36-8 lithium cyanide 
• 10442-39-4 tetra-n-butylammonium cyanide 

Downstream Products

• 161659-80-9 (3S)-1-Benzylpyrrolidine-3-carboxylic acid 
• 1212293-24-7 (S)-1-Benzyl-pyrrolidine-3-carboxylic acid; hydrochloride 
• 216311-58-9 methyl (S)-(+)-1-(phenylmethyl)-3-pyrrolidinecarboxylate 
• 216311-60-3 (3S)-pyrrolidine-3-carboxylic acid methyl ester 
• 229323-04-0 ((R)-1-benzyl-pyrrolidin-3-yl)-methyl-amine 

Relevant academic research and scientific papers

A practical ex-chiral-pool synthesis of β-proline and homo-β-proline

Starting from aspartic acid an efficient synthesis of enantiomerically pure β-proline and homo-β-proline is described. The key step of the synthesis includes formation of the 1,4-biselectrophile 6, followed by rearrangement via the aziridinium intermediate 7 and ring closure to give the pyrrolidinium salt 9a which can serve as a common precursor for both target compounds.

2-Dibenzylaminobutane-1,4-diol: A Versatile Intermediate for a Chirospecific β-amino Acid Synthesis

Starting from the chiral building block 1, which is readily available from natural aspartic acid, a concise and versatile synthesis of optically active β-amino acids including β-proline derivatives is reported.Regioselective transformations of the 1,4-bis-electrophile 2 are facilitated by an anchimeric participation.

An Efficient Method for the Synthesis of (R)-3-(1-Amino-1-methylethyl)pyrrolidines for the Antiinfective Agent, PD 138312

Methylcerium dichloride has been found to undergo bis addition to nitriles to produce tertiary carbinamines with retention of optical purity at the ? position.This result is used in the development of a short, economical synthesis of the 1,8-naphthyridine antiinfective agent, PD 138312.

Process for chiral 3-(1-amino-1,1-bisalkylmethyl)-1-substituted-pyrrolidines

The process for the preparation of chiral 3-(1-amino-1,1-bisalkylmethyl)-1-substituted-pyrrolidines used as key intermediates for the preparation of naphthyridine and quinolone antibacterial agents which comprises reacting readily available chiral 1-subst