3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide

Base Information

Chemical Name:3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide
CAS No.:1307249-95-1
Molecular Formula:C₂₃H₂₈F₂N₂O₂S
Molecular Weight:434.55
Hs Code.:

Synonyms:3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide

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Chemical Property of 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide

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Technology Process of 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide

There total 9 articles about 3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.5%

: 1307250-00-5
2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoic acid trifluoroacetate

: 506-59-2
N,N-dimethylammonium chloride

: 1307249-95-1
3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃; for 5h;

Reference yield:

: 1283095-52-2
tert-butyl 2-[(2-fluorophenyl)methyl]-3-(2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)propanoate

: 1307249-95-1
3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 20 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

Reference yield:

: 1283095-49-7
t-butyl 2-fluorospiro[4,5-dihydrothieno[2,3-c]pyran-7,4'-piperidine]-1'-carboxylate

: 1307249-95-1
3-(2'-fluoro-4',5'-dihydro-1H-spiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-yl)2-(2-fluorobenzyl)-N,N-dimethylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; water / isopropyl alcohol / 6.5 h / 45 °C

2.1: triethylamine / methanol / 5 h / 65 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

3.2: 0.5 h / -78 °C

3.3: -78 - 20 °C

4.1: 20 °C

5.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 5 h / 0 - 20 °C

With hydrogenchloride; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;