2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile

Base Information

Chemical Name:2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile
CAS No.:114574-55-9
Molecular Formula:C₁₆H₂₆N₂O₃Si
Molecular Weight:322.48
Hs Code.:

Synonyms:2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile

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Chemical Property of 2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile

Chemical Property:

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Technology Process of 2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile

There total 4 articles about 2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 114574-54-8
2-(t-butyldimethylsilyloxy)-2-(3,4-dimethoxy-5-nitrophenyl)ethanonitrile

: 114574-55-9
2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile

Guidance literature:: With hydrogen; nickel; In methanol; for 3h; under 760 Torr; Ambient temperature;
DOI:10.1016/S0040-4020(01)87665-1

Reference yield:

: 6635-20-7
isonitrovanillin

: 114574-55-9
2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / sodium hydroxyde, benzyltributylammonium bromide / CH₂Cl₂ / 24 h

2: 83 percent / zinc iodide / acetonitrile / 48 h

3: 95 percent / hydrogen / Raney nickel / methanol / 3 h / 760 Torr / Ambient temperature

With sodium hydroxide; hydrogen; benzyl tri-n-butylammonium bromide; zinc(II) iodide; nickel; In methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4020(01)87665-1

Reference yield:

: 22027-96-9
5-nitroveratral

: 114574-55-9
2-(5-amino-3,4-dimethoxyphenyl)-2-(t-butyldimethylsilyloxy)ethanonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / zinc iodide / acetonitrile / 48 h

2: 95 percent / hydrogen / Raney nickel / methanol / 3 h / 760 Torr / Ambient temperature

With hydrogen; zinc(II) iodide; nickel; In methanol; acetonitrile;
DOI:10.1016/S0040-4020(01)87665-1