N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide

Base Information

• Chemical Name: N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide
• CAS No.: 1104624-41-0
• Molecular Formula: C₂₃H₁₉F₂NO₃S₂
• Molecular Weight: 459.538

Synonyms:N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide

Chemical Property of N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide

Chemical Property:

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Technology Process of N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide

There total 7 articles about N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-(3,4-difluoro-benzyl)-N-(3-formyl-benzo[b]thiophen-2-yl)-benzenesulfonamide (1104624-18-1) + methylmagnesium bromide (75-16-1) → N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide (1104624-41-0)

Guidance literature:

N-(3,4-difluoro-benzyl)-N-(3-formyl-benzo[b]thiophen-2-yl)-benzenesulfonamide; methylmagnesium bromide; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 3h;

With water; ammonium chloride; In tetrahydrofuran; toluene;

Reference yield:

benzenesulfonyl chloride (98-09-9) → N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide (1104624-41-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / 2 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

2.2: 20 °C

3.1: titanium tetrachloride / dichloromethane / 0.25 h / -5 °C

4.1: toluene; tetrahydrofuran / 3 h / 0 - 20 °C

With sodium hydride; titanium tetrachloride; In tetrahydrofuran; pyridine; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

2-(tert-butoxycarbonylamino)benzothiophene (89673-36-9) → N-(3,4-difluoro-benzyl)-N-[3-(1-hydroxy-ethyl)-benzo[b]thiophen-2-yl]-benzenesulfonamide (1104624-41-0)

Guidance literature:

Multi-step reaction with 5 steps

1.1: hydrogenchloride / 1,4-dioxane / 20 °C

2.1: pyridine / 2 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

3.2: 20 °C

4.1: titanium tetrachloride / dichloromethane / 0.25 h / -5 °C

5.1: toluene; tetrahydrofuran / 3 h / 0 - 20 °C

With hydrogenchloride; sodium hydride; titanium tetrachloride; In tetrahydrofuran; 1,4-dioxane; pyridine; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

upstream raw materials:

N-(3,4-difluoro-benzyl)-N-(3-formyl-benzo[b]thiophen-2-yl)-benzenesulfonamide

methylmagnesium bromide

benzenesulfonyl chloride

benzo[b]thiophene-2-carboxylic acid

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