5-Fluoro-4-chromanone

Base Information

• Chemical Name: 5-Fluoro-4-chromanone
• CAS No.: 188826-32-6
• Molecular Formula: C₉H₇FO₂
• Molecular Weight: 166.152
• Hs Code.: 2932990090
• Mol file: 188826-32-6.mol

Synonyms:5-Fluoro-4-chromanone;

Chemical Property of 5-Fluoro-4-chromanone

Chemical Property:

• Refractive Index: 1.54
• Boiling Point: 279.991 °C at 760 mmHg
• Flash Point: 119.357 °C
• PSA: 26.30000
• Density: 1.298 g/cm³
• LogP: 1.79090

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoro-4-chromanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-4-chromanone

There total 8 articles about 5-Fluoro-4-chromanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(2-fluorophenoxy)propanoic acid (2967-72-8) → 5-fluoro-2,3-dihydro-4H-chromen-4-one (188826-32-6)

Guidance literature:

3-(2-fluorophenoxy)propanoic acid; With oxalyl dichloride; at 0 ℃;

With aluminum (III) chloride; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2012.10.095

Reference yield:

C9H8ClFO2 (133077-43-7) → 5-fluoro-2,3-dihydro-4H-chromen-4-one (188826-32-6)

Guidance literature:

With trifluorormethanesulfonic acid; In chloroform; at -65 - 20 ℃; for 17h; Inert atmosphere;

DOI:10.1039/c4md00082j

Reference yield:

2-fluorophenol (367-12-4) → 5-fluoro-2,3-dihydro-4H-chromen-4-one (188826-32-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide / water / Reflux

2.1: oxalyl dichloride / 0 °C

2.2: 20 °C

With oxalyl dichloride; sodium hydroxide; In water; 2.1: |Friedel-Crafts Acylation / 2.2: |Friedel-Crafts Acylation;

DOI:10.1016/j.bmcl.2012.10.095

upstream raw materials:

2-fluorophenol

3-(2-fluorophenoxy)-1-propanol

3-(2-fluorophenoxy)propanoic acid

3-fluorophenol

Downstream raw materials:

8-(5-fluorochroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Refernces

• 1、 Kesteleyn, Bart,Amssoms, Katie,Schepens, Wim,Hache, Geerwin,Verschueren, Wim,Van De Vreken, Wim,Rombauts, Klara,Meurs, Greet,Sterkens, Patrick,Stoops, Bart,Baert, Lieven,Austin, Nigel,Wegner, J?rg,Masungi, Chantal,Dierynck, Inge,Lundgren, Stina,J?nsson, Daniel,Parkes, Kevin,Kalayanov, Genadiy,Wallberg, Hans,Rosenquist, ?sa,Samuelsson, Bertil,Van Emelen, Kristof,Thuring, Jan Willem. "Design and synthesis of HIV-1 protease inhibitors for a long-acting injectable drug application". . p. 310 - 317. Retrieved 2013/02/25.