133077-43-7

Basic information

• Product Name: C₉H₈ClFO₂
• Synonyms: C₉H₈ClFO₂
• CAS NO: 133077-43-7
• Molecular Weight: 202.613
• Mol File: 133077-43-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₉H₈ClFO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₉H₈ClFO₂(133077-43-7)
• EPA Substance Registry System: C₉H₈ClFO₂(133077-43-7)

Safety Data

• Hazardous Substances Data: 133077-43-7(Hazardous Substances Data)

Upstream product

• 133077-42-6 3-(3-fluorophenoxy)propanoic acid 
• 844648-05-1 3-(3-fluorophenoxy)propanenitrile 
• 372-20-3 3-fluorophenol 

Downstream Products

• 188826-32-6 5-fluoro-2,3-dihydro-4H-chromen-4-one 
• 1630952-72-5 8-(5-fluorochroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one 
• 66892-34-0 6-fluoro-4-chromanone 

Relevant articles and documents

Facile access to chiral 4-substituted chromanes through Rh-catalyzed asymmetric hydrogenation

Rh/ZhaoPhos-catalyzed asymmetric hydrogenation of a series of (E)-2-(chroman-4-ylidene)acetates was successfully developed to prepare various chiral 4-substituted chromanes with high yields and excellent enantioselectivities (up to 99percent yield, 98percent ee). Moreover, the gram-scale hydrogenation could be performed well in the presence of 0.02 molpercent catalyst loading (TON = 5000), the hydrogenation product was easily converted to access other important compounds, which demonstrated the synthetic utility of this asymmetric catalytic methodology.