N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Base Information

Chemical Name:N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide
CAS No.:1528546-94-2
Molecular Formula:C₂₅H₁₈F₂N₄O₃
Molecular Weight:460.44
Hs Code.:

Synonyms:N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Chemical Property:

Purity/Quality:: ≥95% ^*data from raw suppliers

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Technology Process of N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

There total 10 articles about N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1528549-08-7
C₃₀H₂₆F₂N₄O₅

: 1528546-94-2
N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 459-04-1
4-Fluorophenylacetyl chloride

: 1528546-94-2
N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: pyridine / dichloromethane / 2.5 h / 0 °C

2.1: ethyl [2]alcohol / 87 °C

2.2: 3 h / 110 °C

3.1: ammonium chloride / ethanol / 2 h / Reflux

4.1: sodium hydroxide / ethanol / 2 h / 65 °C

5.1: HATU; triethylamine / dichloromethane / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With pyridine; ammonium chloride; triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane; ethyl [2]alcohol;

Reference yield:

: 1052114-80-3
ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate

: 1528546-94-2
N-(4-(2,3-dihydro-1H-pyrrolo[2,3-b] pyridin-4-yloxy)-3-fluorophenyl)-5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 2 h / 65 °C

2: HATU; triethylamine / dichloromethane / 20 °C

3: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With triethylamine; HATU; trifluoroacetic acid; sodium hydroxide; In ethanol; dichloromethane;