H-A₂bu(Z)-OH

Base Information

• Chemical Name: H-A₂bu(Z)-OH
• CAS No.: 95766-36-2
• Molecular Formula: C₁₂H₁₆N₂O₄
• Molecular Weight: 252.27
• Mol file: 95766-36-2.mol

Synonyms:H-A₂bu(Z)-OH

Chemical Property of H-A₂bu(Z)-OH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of H-A₂bu(Z)-OH

There total 4 articles about H-A₂bu(Z)-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

N-(benzyloxycarbonyl)-4-amino-2-oxobutyric acid → H-A2bu(Z)-OH (95766-36-2)

Guidance literature:

With phenylglycin; In water; acetonitrile; for 24h; Inert atmosphere; Reflux;

DOI:10.1021/acs.orglett.8b03910

Reference yield:

DL-2,4-diaminobutyric acid dihydrochloride (6970-28-1) + benzyl chloroformate (501-53-1,94274-21-2) → H-A2bu(Z)-OH (95766-36-2)

Guidance literature:

DL-2,4-diaminobutyric acid dihydrochloride; benzyl chloroformate; With sodium hydroxide; copper diacetate; In 1,4-dioxane; at 20 ℃; for 1h;

With hydrogenchloride; ethylenediaminetetraacetic acid; In 1,4-dioxane; for 0.5h; Further stages.;

DOI:10.1021/jm000078q

Reference yield:

dibenzyl dicarbonate (31139-36-3) + L-2,4-diaminobutyric acid (305-62-4,1758-80-1,2577-63-1,26908-94-1,60484-56-2) → 2-Amino-4-benzyloxycarbonylamino-butyric acid (2130-77-0,95766-36-2,101854-50-6)

Guidance literature:

Multistep reaction;

DOI:10.1016/S0040-4039(00)99476-0

upstream raw materials:

DL-2,4-diaminobutyric acid dihydrochloride

benzyl chloroformate

dibenzyl dicarbonate

L-2,4-diaminobutyric acid

Downstream raw materials:

4-(((benzyloxy)carbonyl)amino)-2-((tert-butoxycarbonyl)amino)butanoic acid