5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole

Base Information

• Chemical Name: 5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole
• CAS No.: 917878-64-9
• Molecular Formula: C₁₇H₁₆N₆S₃
• Molecular Weight: 400.552
• Mol file: 917878-64-9.mol

Synonyms:5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole

Chemical Property of 5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole

There total 5 articles about 5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-Phenyl-1H-tetrazole-5-thiol (86-93-1) + (2'-isopropyl-2,4'-bi-1,3-thiazol-4-yl)methanol (551928-63-3) → 5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole (917878-64-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.tet.2006.09.064

Reference yield:

2-isopropyl-thiazole-4-carboxylic acid ethyl ester (133047-44-6) → 5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole (917878-64-9)

Guidance literature:

Multi-step reaction with 5 steps

1: NH₃ / methanol / 72 h / 20 °C

2: 12.53 g / phosphorus pentasulfide / benzene / 2 h / Heating

3: 94 percent / ethanol / 1 h / Heating

4: 91 percent / LiBH₄ / tetrahydrofuran / 2 h / 20 °C

5: 96 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C

With diphosphorus pentasulfide; lithium borohydride; ammonia; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; ethanol; benzene;

DOI:10.1016/j.tet.2006.09.064

Reference yield:

2-isopropylthiazole-4-carbothioic acid amide (416858-68-9) → 5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylsulfanyl)-1-phenyl-1H-tetrazole (917878-64-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / ethanol / 1 h / Heating

2: 91 percent / LiBH₄ / tetrahydrofuran / 2 h / 20 °C

3: 96 percent / triphenylphosphine; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C

With lithium borohydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol;

DOI:10.1016/j.tet.2006.09.064

upstream raw materials:

1-Phenyl-1H-tetrazole-5-thiol

(2'-isopropyl-2,4'-bi-1,3-thiazol-4-yl)methanol

2-isopropyl-thiazole-4-carboxylic acid ethyl ester

2-isopropylthiazole-4-carbothioic acid amide

Downstream raw materials:

5-(2'-isopropyl[2,4']bithiazolyl-4-ylmethylnesulfonyl)-1-phenyl-1H-tetrazole