Technology Process of 2-(Tetrahydro-pyran-4-ylamino)-4-(1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-benzonitrile
There total 9 articles about 2-(Tetrahydro-pyran-4-ylamino)-4-(1,5,5-trimethyl-7-oxo-4,5,6,7-tetrahydro-1H-indazol-3-yl)-benzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
at 80 ℃;
for 4h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium hydroxide; dihydrogen peroxide / methanol; water / -15 - 0 °C
2.1: methanol; potassium hydroxide / 20 °C / Heating / reflux
3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -20 - 20 °C
3.2: 1 h / -78 °C
4.1: acetic acid / methanol / 1.5 h / Heating / reflux
5.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 4 h / 80 °C
With
methanol; potassium hydroxide; sodium hydroxide; dihydrogen peroxide; acetic acid; lithium hexamethyldisilazane; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; methanol; water; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: methanol; potassium hydroxide / 20 °C / Heating / reflux
2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.75 h / -20 - 20 °C
2.2: 1 h / -78 °C
3.1: acetic acid / methanol / 1.5 h / Heating / reflux
4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 4 h / 80 °C
With
methanol; potassium hydroxide; acetic acid; lithium hexamethyldisilazane; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0); 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
tetrahydrofuran; methanol; toluene;
