5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one

Base Information

Chemical Name:5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one
CAS No.:82543-14-4
Molecular Formula:C₂₅H₃₆O₄
Molecular Weight:400.558
Hs Code.:
European Community (EC) Number:617-345-3
DSSTox Substance ID:DTXSID801036464

Synonyms:SCHEMBL855991;FFDPCMQAAUBAQI-BDIDVDKGSA-N;DTXSID801036464;5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one;82543-14-4;NS00004411;5beta-hydroxy-15beta,16beta-methylene-3beta-pivaloyloxyandrost-6-en-17-one;5-hydroxy-15beta,16beta-methylene-3beta-pivaloyloxy-5beta-androst-6-en-17-one

Suppliers and Price of 5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one

Chemical Property:

Boiling Point:494.9±45.0 °C(Predicted)
Density:1.17±0.1 g/cm3(Predicted)
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:400.26135963
Heavy Atom Count:29
Complexity:793

Purity/Quality:: 99.9% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC12CCC(CC1(C=CC3C2CCC4(C3C5CC5C4=O)C)O)OC(=O)C(C)(C)C
Isomeric SMILES:C[C@]12CC[C@@H](C[C@]1(C=C[C@@H]3[C@@H]2CC[C@]4([C@H]3[C@@H]5C[C@@H]5C4=O)C)O)OC(=O)C(C)(C)C

Technology Process of 5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one

There total 1 articles about 5-Hydroxy-15 beta,16 beta-methylene-3 beta-pivaloyloxy-5 beta-androst-6-en-17-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82543-09-7
7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5-androsten-17-one

: 82543-14-4
5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / tert-butylhydroperoxide, VO(C₅H₇O₂)2 / toluene / 2 h / 80 °C

2: 79 percent / P(C₆H₅)3 / CCl₄; CH₂Cl₂; pyridine / 2 h / 0 deg C to room temp.

3: 75 percent / Zn / acetic anhydride; tetrahydrofuran / 1.5 h / 70 °C

With tert.-butylhydroperoxide; VO(C₅H₇O₂)2; triphenylphosphine; zinc; In tetrahydrofuran; pyridine; tetrachloromethane; dichloromethane; acetic anhydride; toluene;

Reference yield:

: 82543-14-4
5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one

: 82543-17-7
17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / KOH, NaClO₄ / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

2: 88 percent / Zn/Cu / 1,2-dimethoxy-ethane / 5 h / 55 °C

3: 69 percent / KOEt / tetrahydrofuran / 2 h / Ambient temperature

With potassium hydroxide; potassium ethoxide; sodium perchlorate; copper; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane;

Reference yield:

: 82543-14-4
5-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5β-androst-6-en-17-one

: 74220-07-8
Spirorenone

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / KOH, NaClO₄ / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

2: 88 percent / Zn/Cu / 1,2-dimethoxy-ethane / 5 h / 55 °C

3: 69 percent / KOEt / tetrahydrofuran / 2 h / Ambient temperature

4: 95 percent / H₂ / Pd/CaCO₃ / tetrahydrofuran; propan-2-ol / 2 h / 750.06 Torr / Ambient temperature

5: 62 percent / pyridinium dichromate / dimethylformamide / 24 h / 70 °C

6: 59 percent / DDQ / dioxane / 1.5 h / 100 °C

With potassium hydroxide; dipyridinium dichromate; potassium ethoxide; sodium perchlorate; hydrogen; copper; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; Lindlar's catalyst; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; isopropyl alcohol;