(1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one

Base Information

Chemical Name:(1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one
CAS No.:213026-20-1
Molecular Formula:C₂₄H₃₆O₅
Molecular Weight:404.547
Hs Code.:

Synonyms:(1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one

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Technology Process of (1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one

There total 19 articles about (1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 213026-16-5
C₂₆H₄₀O₆

: 213026-20-1
(1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo9805192

Reference yield: 89.0%

: 259194-83-7
(4aS,5S,8aS)-5,8a-Dimethyl-6-methylene-5-(2,3,5,6-tetramethoxy-benzyl)-octahydro-naphthalen-1-one

: 213026-20-1
(1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one

: 388120-09-0
(1R,2R,4aS)-trans-decahydro-1α-[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2α,4aβ-trimethyl-naphthalen-5-one

Guidance literature:: With hydrogen; triethylamine; 10percent Pd/C; In methanol; at 20 ℃; for 12h;
DOI:10.1021/ja011413i

Reference yield:

: 2441-46-5
1,2,4,5-tetramethoxybenzene

: 213026-20-1
(1R,2S,4aS)-trans-decahydro-1α[(2,3,5,6-tetramethoxyphenyl)methyl]-1β,2β,4aβ-trimethyl-naphthalen-5-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 74 percent / HBr; AcOH / 16 h / 20 °C

2.1: Li; NH₃ / tetrahydrofuran; H₂O / 0.75 h / -78 - -33 °C

2.2: 76 percent / tetrahydrofuran; H₂O / 2 h / Heating

3.1: 98 percent / KOtBu / toluene / 4 h / Heating

4.1: 100 percent / HCl / tetrahydrofuran / 12 h / 20 °C

5.1: 89 percent / H₂; Et₃N / 10percent Pd/C / methanol / 12 h / 20 °C

With hydrogenchloride; potassium tert-butylate; ammonia; hydrogen bromide; hydrogen; lithium; acetic acid; triethylamine; 10percent Pd/C; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/ja011413i