1,2,4,5-Tetramethoxybenzene

Base Information

• Chemical Name: 1,2,4,5-Tetramethoxybenzene
• CAS No.: 2441-46-5
• Molecular Formula: C10H14O4
• Molecular Weight: 198.219
• Hs Code.: 29093090
• NSC Number: 144256
• DSSTox Substance ID: DTXSID00179164
• Nikkaji Number: J614.155B
• Wikidata: Q83049676
• Mol file: 2441-46-5.mol

Synonyms:1,2,4,5-tetramethoxybenzene;1,2,4,5-TMB

Chemical Property of 1,2,4,5-Tetramethoxybenzene

Chemical Property:

• Vapor Pressure: 0.00694mmHg at 25°C
• Melting Point: 102.5 °C
• Refractive Index: 1.483
• Boiling Point: 279.1 °C at 760 mmHg
• Flash Point: 112.5 °C
• PSA: 36.92000
• Density: 1.068 g/cm³
• LogP: 1.72100
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 198.08920892
• Heavy Atom Count: 14
• Complexity: 128

Purity/Quality:

98%min ^*data from raw suppliers

1,2,4,5-Tetramethoxybenzene 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1OC)OC)OC

Technology Process of 1,2,4,5-Tetramethoxybenzene

There total 24 articles about 1,2,4,5-Tetramethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,4,5-trimethoxyphenol (20491-91-2) + methyl iodide (74-88-4) → 1,2,4,5-tetramethoxybenzene (2441-46-5)

Guidance literature:

2,4,5-trimethoxyphenol; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 13h;

Reference yield: 94.0%

2,5-dimethoxyquinone (3117-03-1) + methyl iodide (74-88-4) → 1,2,4,5-tetramethoxybenzene (2441-46-5)

Guidance literature:

2,5-dimethoxyquinone; With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; for 0.333333h;

methyl iodide; In dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2014.03.045

Reference yield: 93.0%

1,2,4,5-benzenetetrol (636-32-8) + dimethyl sulfate (77-78-1) → 1,2,4,5-tetramethoxybenzene (2441-46-5)

Guidance literature:

With potassium carbonate; In acetone; for 16h; Reflux;

DOI:10.1039/c8ob02596g

upstream raw materials:

2-methoxy-4,5-di-acetoxyphenyl acetate

2,5-dimethoxyquinone

2,5-dimethoxyhydroquinone

methyl iodide

Downstream raw materials:

2,3,5,6-tetramethoxybenzaldehyde

1,4-dibromo-2,3,5,6-tetramethoxybenzene

3-undecyl-1,2,4,5-tetramethoxybenzene

(Z)-1-(2,3,5,6-tetramethoxyphenyl)-8-heptadecene

Refernces

• 1、 Amesty, ángel,Estévez-Braun, Ana,Fernández-Pérez, Leandro,Guerra, Borja,Guerra-Rodríguez, Miguel,Martín-Acosta, Pedro. "Modular synthesis and antiproliferative activity of new dihydro-1H-pyrazolo[1,3-b]pyridine embelin derivatives". . . Retrieved 2021/10/22.
• 2、 Bai, Yajun,He, Xirui,Bai, Yujun,Sun, Ying,Zhao, Zefeng,Chen, Xufei,Li, Bin,Xie, Jing,Li, Yang,Jia, Pu,Meng, Xue,Zhao, Ye,Ding, Yanrui,Xiao, Chaoni,Wang, Shixiang,Yu, Jie,Liao, Sha,Zhang, Yajun,Zhu, Zhiling,Zhang, Qiang,Zhao, Yuhui,Qin, Fanggang,Zhang, Yi,Wei, Xiaoyang,Zeng, Min,Liang, Jing,Cuan, Ye,Shan, Guangzhi,Fan, Tai-Ping,Wu, Biao,Zheng, Xiaohui. "Polygala tenuifolia-Acori tatarinowii herbal pair as an inspiration for substituted cinnamic α-asaronol esters: Design, synthesis, anticonvulsant activity, and inhibition of lactate dehydrogenase study". . . Retrieved 2019/09/18.