(Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

Base Information

Chemical Name:(Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate
CAS No.:1372465-76-3
Molecular Formula:C₂₉H₃₄N₄O₈S
Molecular Weight:598.677
Hs Code.:

(Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

Synonyms:(Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

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Chemical Property of (Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

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Technology Process of (Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

There total 5 articles about (Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (Z)-tert-butyl 4-((6-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

: 105-36-2
ethyl bromoacetate

: 1372465-76-3
(Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

Guidance literature:: (Z)-tert-butyl 4-((6-(4-((2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 30 ℃; for 1h;

ethyl bromoacetate; In N,N-dimethyl-formamide; at 0 - 30 ℃; for 3h;

Reference yield:

: 4316-97-6
4,6-dichloro-5-methylpyrimidine

: 1372465-76-3
(Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0 - 30 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 24 h / 70 °C

3.1: benzoic acid; piperidine / toluene / 7 h / Reflux

4.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 30 °C

4.2: 3 h / 0 - 30 °C

With piperidine; potassium tert-butylate; sodium hydride; caesium carbonate; benzoic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1372467-40-7
tert-butyl 4-((6-(4-formylphenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

: 1372465-76-3
(Z)-tert-butyl 4-((6-(4-((3-(2-ethoxy-2-oxoethyl)-2,4-dioxothiazolidin-5-ylidene)methyl)phenoxy)-5-methylpyrimidin-4-yl)oxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzoic acid; piperidine / toluene / 7 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 0 - 30 °C

2.2: 3 h / 0 - 30 °C

With piperidine; sodium hydride; benzoic acid; In N,N-dimethyl-formamide; toluene;