(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

Base Information

Chemical Name:(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine
CAS No.:146918-97-0
Molecular Formula:C₃₀H₃₀N₂O₇S
Molecular Weight:563.635
Hs Code.:

Synonyms:(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

Suppliers and Price of (2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

There total 13 articles about (2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 124-63-0
methanesulfonyl chloride

: 146918-96-9
C₂₉H₂₇⁽²⁾HN₂O₅

: 146918-97-0
(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

Guidance literature:: With pyridine; for 1h; Ambient temperature;
DOI:10.1016/S0040-4020(01)85754-9

Reference yield:

: 134953-45-0
1-(3',5'-di-O-benzyl-β-D-xylo-furanosyl)thymine

: 146918-97-0
(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

2: 74 percent / Py-HBr / pyridine / 3 h / Heating

3: 77 percent / Bu₃SnCl, NaBD₄ / methanol / 3 h / Irradiation

4: 85 percent / H₂ / 10percent Pd/C / methanol / 8 h / 2327.2 Torr

5: 77 percent / pyridine / 1 h / 90 °C

6: 91 percent / pyridine / 1 h / Ambient temperature

With pyridine; sodium borodeuteride; tributyltin chloride; hydrogen; Pyridine hydrobromide; triethylamine; palladium on activated charcoal; In pyridine; methanol; dichloromethane;
DOI:10.1016/S0040-4020(01)85754-9

Reference yield:

: 146918-94-7
1-(3',5'-di-O-benzyl-2'-O-mesyl-β-D-xylo-furanosyl)thymine

: 146918-97-0
(2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / Py-HBr / pyridine / 3 h / Heating

2: 77 percent / Bu₃SnCl, NaBD₄ / methanol / 3 h / Irradiation

3: 85 percent / H₂ / 10percent Pd/C / methanol / 8 h / 2327.2 Torr

4: 77 percent / pyridine / 1 h / 90 °C

5: 91 percent / pyridine / 1 h / Ambient temperature

With pyridine; sodium borodeuteride; tributyltin chloride; hydrogen; Pyridine hydrobromide; palladium on activated charcoal; In pyridine; methanol;
DOI:10.1016/S0040-4020(01)85754-9