146918-96-9

Upstream product

• 134953-45-0 1-(3',5'-di-O-benzyl-β-D-xylo-furanosyl)thymine 
• 76-83-5 trityl chloride 
• 147199-93-7 C₁₀H₁₃⁽²⁾HN₂O₅ 
• 146986-45-0 1,2-di-O-acetyl-3,5-di-O-benzyl-α/β-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 16054-77-6 3,5-di-O-benzyl-D-xylofuranose 
• 134953-44-9 (2'-O-acetyl-3',5'-di-O-benzyl-β-D-xylofuranosyl)-thymine 
• 41341-99-5 3,5-di-O-benzyl-1,2-O-isopropylidene-α-D-xylofuranose 
• 146918-94-7 1-(3',5'-di-O-benzyl-2'-O-mesyl-β-D-xylo-furanosyl)thymine 
• 146933-27-9 (2'R)(3',5'-di-O-benzyl-2'-deoxy-2'-deutero-β-D-xylofuranosyl)thymine 
• 146918-95-8 (2'-bromo-3',5'-di-O-benzyl-2'-deoxy-β-D-xylofuranosyl)thymine 

Downstream Products

• 146918-98-1 C₂₉H₂₆⁽²⁾HN₅O₄ 
• 146918-97-0 (2'R)(2'-deoxy-2'-deutero-3'-O-mesyl-5'-O-trityl-β-D-xylofuranosyl)thymine 

Relevant academic research and scientific papers

Syntheses and conformational studies on AZT and its deuterated analogues

The NMR spectrum of 3′-azido-3′-deoxythymidine (AZT) in aqueous solution provides sum of some of the proton-proton coupling constants. This limitation precludes the determination of the pseudorotational parameters of the sugar ring. Selective deuteration alleviates this problem. The synthesis of 2′-deutero and 3′-deutero- AZT have been described for the first time starting from D-xylose and β-thymidine respectively. NMR study of these analogues in aqueous solutions shows that almost equal amount of C-2′-endo and C-3′-endo species exist in equilibrium.