benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate

Base Information

Chemical Name:benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate
CAS No.:1204431-36-6
Molecular Formula:C₂₃H₂₃ClN₂O₅S
Molecular Weight:474.965
Hs Code.:

Synonyms:benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate

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Chemical Property of benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate

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Technology Process of benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate

There total 7 articles about benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: benzhydryl 7-(allyloxycarbonylamino)-3-(chloroacetoxy)-3-methylcephalosporanate

: 211623-26-6
benzhydryl 6-(Allyloxycarbonylamino)-2'β-(chloroacetoxy)penicillinate

: 1204431-36-6
benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate

: 211623-28-8
benzhydryl 6-amino-2'β-(chloroacetoxy)penicillinate

Guidance literature:: benzhydryl 7-(allyloxycarbonylamino)-3-(chloroacetoxy)-3-methylcephalosporanate; benzhydryl 6-(Allyloxycarbonylamino)-2'β-(chloroacetoxy)penicillinate; With tri-n-butyl-tin hydride; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 79-11-8
chloroacetic acid

: 211623-25-5
(R)-benzhydryl 2-((2R,3R)-3-(allyloxycarbonyl)amino-2-(benzo[d]thiazol-2-yldisulfanyl)-4-oxoazetidin-1-yl)-3-methylbut-3-enoate

: 1204431-36-6
benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate

: 211623-28-8
benzhydryl 6-amino-2'β-(chloroacetoxy)penicillinate

Guidance literature:: chloroacetic acid; (R)-benzhydryl 2-((2R,3R)-3-(allyloxycarbonyl)amino-2-(benzo[d]thiazol-2-yldisulfanyl)-4-oxoazetidin-1-yl)-3-methylbut-3-enoate; With silver(I) acetate; In dichloromethane; at 20 ℃; for 3h;

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; acetic acid; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/ja104092z

Reference yield:

: 947589-45-9
benzhydryl 6-(allyloxycarbonylamino)penicillinate-1-oxide

: 1204431-36-6
benzhydryl 7-amino-3-(chloroacetoxy)-3-methylcephalosporanate

: 211623-28-8
benzhydryl 6-amino-2'β-(chloroacetoxy)penicillinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / 1,4-dioxane / 14 h / 110 °C

2.1: silver(I) acetate / ethyl acetate / 20 °C

2.2: 20 °C

With silver(I) acetate; magnesium sulfate; In 1,4-dioxane; ethyl acetate;
DOI:10.1021/acs.jmedchem.0c00127