(2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate

Base Information

Chemical Name:(2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate
CAS No.:1448668-04-9
Molecular Formula:C₂₁H₂₃NO₄
Molecular Weight:353.418
Hs Code.:

Synonyms:(2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate

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Chemical Property of (2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate

Chemical Property:

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Technology Process of (2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate

There total 5 articles about (2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1871-76-7
diphenylacetic acid chloride

: 175671-43-9,337464-25-2
(2S,4R)-methyl 4-hydroxypiperidine-2-carboxylate hydrochloride

: 1448668-04-9
(2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In dichloromethane; water; at 20 ℃; for 20h;

Reference yield:

: 1871-76-7
diphenylacetic acid chloride

: 211058-80-9,189952-45-2
methyl 4(R)-hydroxypiperidine-2(S)-carboxylate

: 1448668-04-9
(2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate

Guidance literature:: With potassium carbonate; In water; ethyl acetate; at 0 - 20 ℃; for 1.5h; Time;

Reference yield:

: 1799811-83-8
1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate

: 1448668-04-9
(2S,4R)-methyl 1-(2,2-diphenylacetyl)-4-hydroxypiperidine-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: L-Selectride / tetrahydrofuran / 1 h / -78 °C

2: hydrogenchloride / methanol / 20 °C

3: potassium carbonate / water; ethyl acetate / 1.5 h / 0 - 20 °C

With hydrogenchloride; L-Selectride; potassium carbonate; In tetrahydrofuran; methanol; water; ethyl acetate;