5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Base Information

Chemical Name:5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide
CAS No.:1426940-31-9
Molecular Formula:C₃₀H₂₂F₂N₄O₄S₂
Molecular Weight:604.658
Hs Code.:

Synonyms:5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

There total 8 articles about 5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.1%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1426942-61-1
2-(5-bromopyridin-3-yl)-4-fluorobenzo[d]thiazole

: 1426940-31-9
5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 15h; Inert atmosphere;

Reference yield: 29.1%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1426942-58-6
3-(benzo[b]thiophen-2-yl)-5-chloropyridine

: 1426940-31-9
5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; In 1,4-dioxane; water; at 100 ℃; for 15h; Inert atmosphere;

Reference yield:

: 20826-04-4
5-bromo-3-pyridinecarboxylic acid

: 1426940-31-9
5-(5-(4-fluorobenzo[d]thiazol-2-yl)pyridin-3-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / dichloromethane / 2 h / Reflux

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: Lawessons reagent / toluene / 15 h / Reflux

4: sodium hydride / toluene; N,N-dimethyl-formamide / 2.5 h / 0 °C / Reflux

5: potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 15 h / 100 °C / Inert atmosphere

With Lawessons reagent; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; thionyl chloride; sodium hydride; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; 5: |Suzuki Coupling;