4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER

Base Information

• Chemical Name: 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER
• CAS No.: 7210-73-3
• Molecular Formula: C7H9NO2S
• Molecular Weight: 171.22
• Hs Code.: 2934100090
• Mol file: 7210-73-3.mol

Synonyms:4-Methylthiazole-2-carboxylicacid ethyl ester;Ethyl 4-methylthiazole-2-carboxylate;ethyl 4-methyl-1,3-thiazole-2-carboxylate;2-Thiazolecarboxylic acid, 4-methyl-, ethyl ester;Ethyl 4-methyl-1,3-thiazole-2-carboxylate;

Chemical Property of 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER

Chemical Property:

• Boiling Point: 248.7 °C at 760 mmHg
• PKA: 0.85±0.10(Predicted)
• Flash Point: 104.2 °C
• PSA: 67.43000
• Density: 1.198 g/cm³
• LogP: 1.62820
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl4-methylthiazole-2-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER

There total 3 articles about 4-METHYLTHIAZOLE-2-CARBOXYLIC ACID ETHYLESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

ethyl 2-amino-2-thioxoacetate (16982-21-1) + chloroacetone (78-95-5) → 4-Methylthiazol-2-carbonsaeure-ethylester (7210-73-3)

Guidance literature:

In acetonitrile; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.tetlet.2017.07.085

Reference yield:

ethyl 2-amino-2-thioxoacetate (16982-21-1) + acetone (67-64-1) → 4-Methylthiazol-2-carbonsaeure-ethylester (7210-73-3)

Guidance literature:

In ethanol; for 0.5h; Heating;

DOI:10.1039/P19810002335

Reference yield:

ethyl 2-amino-2-thioxoacetate (16982-21-1) + 1-bromoacetone (598-31-2) → 4-Methylthiazol-2-carbonsaeure-ethylester (7210-73-3)

Guidance literature:

upstream raw materials:

ethyl 2-amino-2-thioxoacetate

chloroacetone

1-bromoacetone

acetone

Downstream raw materials:

2-Ethoxycarbonyl-3,4-dimethyl-thiazolium-(2,4-dinitro-benzolsulfonat)

2-ethoxycarbonyl-3,4-dimethyl-thiazolium; toluene-4-sulfonate

2-(7-(4-methoxybenzyl)-8-methyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazin-3-yl)-4-methylthiazole

(8-methyl-3-(4-methylthiazol-2-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)(4-(thiophen-2-yl)phenyl)methanone

Refernces

• 1、 Vu, Hoang Nam,Kim, Ji Young,Hassan, Ahmed H.E.,Choi, Kihang,Park, Jong-Hyun,Park, Ki Duk,Lee, Jae Kyun,Pae, Ae Nim,Choo, Hyunah,Min, Sun-Joon,Cho, Yong Seo. "Synthesis and biological evaluation of picolinamides and thiazole-2-carboxamides as mGluR5 (metabotropic glutamate receptor 5) antagonists". supporting information. p. 140 - 144. Retrieved 2015/12/18.
• 2、 -. "THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES". Page/Page column 46. . Retrieved 2008/06/13.