1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ⁶-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione

Base Information

• Chemical Name: 1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ⁶-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione
• CAS No.: 246858-22-0
• Molecular Formula: C₁₇H₁₁N₃O₆S
• Molecular Weight: 385.357

Synonyms:1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ⁶-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione

Chemical Property of 1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ⁶-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione

Chemical Property:

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Technology Process of 1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ⁶-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione

There total 3 articles about 1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ⁶-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

saccharin (81-07-2) + N-chloromethyl-N'-phenyl-2,4,5-imidazolidinetrione (170379-67-6) → 1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ6-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione (246858-22-0)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 - 60 ℃; for 5.5h; Inert atmosphere;

DOI:10.14233/ajchem.2013.13307a

Reference yield:

N-hydroxymethyl-N'-phenyl-2,4,5-imidazolidinetrione → 1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ6-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione (246858-22-0)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: triethylamine / tetrahydrofuran / 5.5 h / 20 - 60 °C / Inert atmosphere

With thionyl chloride; triethylamine; In tetrahydrofuran;

DOI:10.14233/ajchem.2013.13307a

Reference yield:

N-phenylparabanic acid (2211-33-8) → 1-phenyl-3-(1,1,3-trioxo-2,3-dihydro-1λ6-benzo[d]isothiazol-2-ylmethyl)imidazolidine-2,4,5-trione (246858-22-0)

Guidance literature:

Multi-step reaction with 3 steps

1: water / Alkaline conditions

2: thionyl chloride

3: triethylamine / tetrahydrofuran / 5.5 h / 20 - 60 °C / Inert atmosphere

With thionyl chloride; triethylamine; In tetrahydrofuran; water;

DOI:10.14233/ajchem.2013.13307a

upstream raw materials:

N-phenylparabanic acid

saccharin

N-chloromethyl-N'-phenyl-2,4,5-imidazolidinetrione

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