3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine

Base Information

Chemical Name:3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine
CAS No.:1308869-24-0
Molecular Formula:C₃₀H₃₃N₃
Molecular Weight:435.612
Hs Code.:

Synonyms:3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine

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Chemical Property of 3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine

Chemical Property:

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Technology Process of 3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine

There total 12 articles about 3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308870-46-3
3-(2-(5-(cyclohexenyl)pyridin-3-yl)prop-1-enyl)-6-o-tolylquinolin-2-amiE

: 1308869-24-0
3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 15h;

Reference yield:

: 38940-62-4
3-acetyl-5-bromopyridine

: 1308869-24-0
3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 8 steps

1.1: ethanol; sodium tetrahydroborate / 0.5 h / 20 °C

2.1: thionyl chloride / dichloromethane / 4 h / 20 °C

3.1: lithium bromide / 1,4-dioxane / 120 °C / Sealed vessel

4.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0 °C / Inert atmosphere

4.2: 1.67 h / 20 °C / Cooling with ice

5.1: 1-methyl-pyrrolidin-2-one / 1.17 h / 200 °C

6.1: trifluoroacetic acid / 1 h / 90 °C

7.1: potassium acetate / bis(tri-tert-butylphasphine)palladium dichloride / acetonitrile; water / 0.17 h / 120 °C / Microwave irradiation

8.1: hydrogen / palladium 10% on activated carbon / ethanol / 15 h

With sodium tetrahydroborate; thionyl chloride; ethanol; hydrogen; potassium acetate; potassium hexamethylsilazane; trifluoroacetic acid; lithium bromide; bis(tri-tert-butylphasphine)palladium dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; toluene; acetonitrile;

Reference yield:

: 283608-66-2
1-(5-bromo-pyridin-3-yl)-ethanol

: 1308869-24-0
3-(2-(5-cyclohexylpyridin-3-yl)propyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride / dichloromethane / 4 h / 20 °C

2.1: lithium bromide / 1,4-dioxane / 120 °C / Sealed vessel

3.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 0 °C / Inert atmosphere

3.2: 1.67 h / 20 °C / Cooling with ice

4.1: 1-methyl-pyrrolidin-2-one / 1.17 h / 200 °C

5.1: trifluoroacetic acid / 1 h / 90 °C

6.1: potassium acetate / bis(tri-tert-butylphasphine)palladium dichloride / acetonitrile; water / 0.17 h / 120 °C / Microwave irradiation

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 15 h

With thionyl chloride; hydrogen; potassium acetate; potassium hexamethylsilazane; trifluoroacetic acid; lithium bromide; bis(tri-tert-butylphasphine)palladium dichloride; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; toluene; acetonitrile;