3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate

Base Information

• Chemical Name: 3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate
• CAS No.: 1292687-94-5
• Molecular Formula: C₁₈H₂₀O₇S
• Molecular Weight: 380.419
• Mol file: 1292687-94-5.mol

Synonyms:3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate

Chemical Property of 3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate

There total 14 articles about 3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-(3-hydroxy-2,6-dimethylbenzyloxy)-4-methylphenyl)acetic acid (1292687-92-3) → 3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate (1292687-94-5)

Guidance literature:

With pyridine; sulfur trioxide pyridine complex; at 20 ℃; for 24h;

Reference yield:

methyl 2,6-dimethyl-3-hydroxybenzene-1-carboxylate (131236-69-6) → 3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate (1292687-94-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

5.1: sodium hydroxide; ethanol / 3 h / 20 °C

5.2: pH 3.5 - 4

6.1: pyridine; sulfur trioxide pyridine complex / 24 h / 20 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

2,6-dimethylbenzoic acid (632-46-2) → 3-((5-(carboxymethyl)-2-methylphenoxy)methyl)-2,4-dimethylphenyl sulfate (1292687-94-5)

Guidance literature:

Multi-step reaction with 10 steps

1.1: nitric acid; sulfuric acid / nitromethane / 21 h / 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

3.1: tin(II) chloride dihdyrate / ethanol / 2 h / 80 °C

3.2: pH 5

4.1: water; sodium nitrite; sulfuric acid / 0 - 120 °C

5.1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 0 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

7.1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 4 h / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 0 °C

9.1: sodium hydroxide; ethanol / 3 h / 20 °C

9.2: pH 3.5 - 4

10.1: pyridine; sulfur trioxide pyridine complex / 24 h / 20 °C

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; tin(II) chloride dihdyrate; ethanol; di-isopropyl azodicarboxylate; sulfuric acid; tetrabutyl ammonium fluoride; water; nitric acid; sulfur trioxide pyridine complex; potassium carbonate; triphenylphosphine; sodium hydroxide; sodium nitrite; In tetrahydrofuran; nitromethane; ethanol; N,N-dimethyl-formamide;

upstream raw materials:

methyl 2,6-dimethyl-3-hydroxybenzene-1-carboxylate

2,6-dimethylbenzoic acid

3-amino-2,6-dimethyl-benzoic acid methyl ester

2,6-dimethyl-3-nitrobenzoic acid