tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate

Base Information

• Chemical Name: tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate
• CAS No.: 1353891-52-7
• Molecular Formula: C₁₉H₂₀Cl₂N₂O₄
• Molecular Weight: 411.285
• Mol file: 1353891-52-7.mol

Synonyms:tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate

Chemical Property of tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate

There total 25 articles about tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-chlorophenylnitromethane (29559-24-8) + tert-butyl 4-chlorobenzylidenecarbamate (779342-75-5) → tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate (1353891-52-7)

Guidance literature:

H,⁽⁴⁾pyrrolidine(6,7)(MeO)2Quin-BAM; In toluene; at -78 ℃; for 24h; Product distribution / selectivity;

Reference yield: 72.0%

4-chlorophenylnitromethane (29559-24-8) + (E)-tert-butyl 4-chlorobenzylidenecarbamate → tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate (1353891-52-7)

Guidance literature:

With N-((1R,2R)-2-((4-(pyrrolidin-1-yl)quinolin-2-yl)amino)cyclohexyl)-3,5-bis(trifluoromethyl)benzamide; In toluene; at -20 ℃; stereoselective reaction;

Reference yield:

4-chlorophenylnitromethane (29559-24-8) + (E)-tert-butyl 4-chlorobenzylidenecarbamate → tert-butyl ((1R,2S)-1,2-bis(4-chlorophenyl)-2-nitroethyl)carbamate (1353891-52-7) + C19H20Cl2N2O4

Guidance literature:

With (1R,2R)-N₁,N₂-bis(8-methoxy-4-(pyrrolidin-1-yl)quinolin-2-yl)cyclohexane-1,2-diamine; In toluene; at -78 ℃; Overall yield = 97 %; stereoselective reaction;

upstream raw materials:

4-chlorophenylnitromethane

tert-butyl 4-chlorobenzylidenecarbamate

para-chlorotoluene

4-chlorobenzyl bromide

Downstream raw materials:

nutlin-3a

tert-butyl ((1R,2S)-2-amino-1,2-bis(4-chlorophenyl)ethyl)carbamate

N-((1S,2R)-2-amino-1,2-bis(4-chlorophenyl)ethyl)-2-isopropoxy-4-methoxybenzamide

tert-butyl (1R,2S)-1,2-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxybenzamido)ethylcarbamate