trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Base Information

Chemical Name:trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide
CAS No.:1310475-78-5
Molecular Formula:C₂₇H₃₅FN₂O₅S
Molecular Weight:518.65
Hs Code.:

Synonyms:trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

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Chemical Property of trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

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Technology Process of trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

There total 4 articles about trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 137-43-9
Cyclopentyl bromide

: 1310473-43-8
trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

: 1310475-78-5
trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Reference yield:

: 914261-11-3
4-Hydroxy-3-methoxy-benzenesulphonyl chloride

: 1310475-78-5
trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1310478-73-9
(1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride

: 1310475-78-5
trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With potassium carbonate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;