(1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride

Base Information

• Chemical Name: (1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride
• CAS No.: 1310478-73-9
• Molecular Formula: C₁₅H₂₁FN₂O*ClH
• Molecular Weight: 300.804

Synonyms:(1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride

Chemical Property of (1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride

Chemical Property:

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Technology Process of (1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride

There total 1 articles about (1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride (1310478-73-9)

Guidance literature:

Reference yield:

4-Hydroxy-3-methoxy-benzenesulphonyl chloride (914261-11-3) + (1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride (1310478-73-9) → trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide (1310473-43-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

1-methyl-1H-indole-5-sulfonyl chloride (859850-75-2) + (1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride (1310478-73-9) → (1r,1r)-N-((R)-1-(4-fluorophenyl)ethyl)-4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxamide (1357271-82-9)

Guidance literature:

With triethylamine; In dichloromethane; acetonitrile; at 20 ℃;

Downstream raw materials:

trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

trans-4-(4-cyclopentyloxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

(1r,1r)-N-((R)-1-(4-fluorophenyl)ethyl)-4-(1-methyl-1H-indole-5-sulfonamido)cyclohexanecarboxamide

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