trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Base Information

Chemical Name:trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide
CAS No.:1310473-43-8
Molecular Formula:C₂₂H₂₇FN₂O₅S
Molecular Weight:450.531
Hs Code.:

Synonyms:trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

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Chemical Property of trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

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Technology Process of trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

There total 2 articles about trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 914261-11-3
4-Hydroxy-3-methoxy-benzenesulphonyl chloride

: 1310478-73-9
(1r,4r)-4-amino-N-((R)-1-(4-fluorophenyl)ethyl)cyclohexanecarboxamide hydrochloride

: 1310473-43-8
trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 914261-11-3
4-Hydroxy-3-methoxy-benzenesulphonyl chloride

: 1310479-56-1
trans-4-amino-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

: 1310473-43-8
trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

Guidance literature:: 4-Hydroxy-3-methoxy-benzenesulphonyl chloride; With N,N'-bis(trimethylsilyl)urea; In dichloromethane; at 20 ℃; for 0.5h;

trans-4-amino-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

Reference yield: 42.0%

: 75-30-9
2-iodo-propane

: 1310473-43-8
trans-4-(4-hydroxy-3-methoxy-benzenesulfonylamino)-cyclohexanecarboxylic acid [(R)-1-(4-fluoro-phenyl)-ethyl]-amide

: 1310475-79-6
Trans-N-((R)-1-(4-Fluorophenyl)ethyl)-4-(4-isopropoxy-3-methoxyphenylsulfonamido)cyclohexanecarboxamide

Guidance literature:: With potassium carbonate; tetra-(n-butyl)ammonium iodide; In water; N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;