2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

Base Information

Chemical Name:2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid
CAS No.:180134-15-0
Molecular Formula:C10H6F6O3
Molecular Weight:288.146
Hs Code.:2918990090
DSSTox Substance ID:DTXSID20372418
Nikkaji Number:J734.054K
Wikidata:Q72489383
Mol file:180134-15-0.mol

Synonyms:2-methoxy-4,6-bis(trifluoromethyl)benzoic acid;180134-15-0;2,4-BIS(TRIFLUOROMETHYL)-6-METHOXYBENZOIC ACID;2-Methoxy-4,6-ditrifluoromethylbenzoic acid;2-METHOXY-4,6-DI(TRIFLUOROMETHYL)BENZOIC ACID;6-Methoxy-2,4-bis(trifluoromethyl)benzoic acid;MFCD00728738;Maybridge1_007918;C10H6F6O3;4,6-ditrifluoromethyl-2-methoxybenzoic acid;SCHEMBL420816;HMS563P20;DTXSID20372418;CCG-40952;CL8099;AKOS005255680;AM83995;TS-01042;FT-0651155;2-methoxy-4,6-bis(trifluoromethyl)benzoicacid;2-methoxy-4,6-bis(trifluoromethy)benzoic acid;2-Methoxy-4,6-bis-trifluoromethyl-benzoic acid;2,4-Bis(trifluoromethyl)-6-methoxy-benzoic acid;2-(methyloxy)-4,6-bis(trifluoromethyl)benzoic acid;Benzoic acid, 2-methoxy-4,6-bis(trifluoromethyl)-;SR-01000631059-1;4,6-DI(TRIFLUOROMETHYL)-2-METHOXYBENZOIC ACID

Suppliers and Price of 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-Methoxy-4,6-bis(trifluoromethyl)benzoicAcid
50mg
$ 60.00

SynQuest Laboratories
2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid
5 g
$ 149.00

SynQuest Laboratories
2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid
10 g
$ 261.00

Matrix Scientific
2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid 97%
1g
$ 176.00

Matrix Scientific
2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid 97%
10g
$ 1260.00

Crysdot
2-Methoxy-4,6-bis(trifluoromethyl)benzoicacid 97%
10g
$ 392.00

Chemenu
2-Methoxy-4,6-bis(trifluoromethyl)benzoicacid 95+%
10g
$ 371.00

Atlantic Research Chemicals
2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid 95%
Price $/1gm:
$ 60.34

Atlantic Research Chemicals
2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid 95%
Price $/250mgs:
$ 19.06

AOBChem
2-Methoxy-4,6-bis(trifluoromethyl)benzoicacid 97%
5g
$ 164.00

Total 29 raw suppliers

Chemical Property of 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

Chemical Property:

Vapor Pressure:0.009mmHg at 25°C
Melting Point:156-159℃
Refractive Index:1.43
Boiling Point:253.641 °C at 760 mmHg
Flash Point:107.199 °C
PSA：46.53000
Density:1.493 g/cm³
LogP:3.43100
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:2
Exact Mass:288.02211302
Heavy Atom Count:19
Complexity:337

Purity/Quality:

99%, ^*data from raw suppliers

2-Methoxy-4,6-bis(trifluoromethyl)benzoicAcid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=C1C(=O)O)C(F)(F)F)C(F)(F)F

Technology Process of 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid

There total 6 articles about 2-Methoxy-4,6-bis(trifluoromethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.2%

: 124-38-9,18923-20-1
carbon dioxide

: 349-60-0
1-methoxy-3,5-bis(trifluoromethyl)benzene

: 180134-15-0
2,4-Bis(trifluoromethyl)-6-methoxybenzoic acid

Guidance literature:: With n-butyllithium; In diethyl ether; for 2h; Ambient temperature;
DOI:10.1016/0022-1139(96)03418-5

Reference yield:

: 618-83-7
5-Hydroxyisophthalic acid

: 180134-15-0
2,4-Bis(trifluoromethyl)-6-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 52 percent / HF, SF₄ / 20 h / 60 °C

2: 82 percent / KOH / 1.) MeOH, 2.) THF, room temp., overnight; reflux, 3 h

3: 84.2 percent / n-BuLi / diethyl ether / 2 h / Ambient temperature

With potassium hydroxide; n-butyllithium; sulfur tetrafluoride; hydrogen fluoride; In diethyl ether;
DOI:10.1016/0022-1139(96)03418-5

Reference yield:

: 349-58-6
3,5-bis-(trifluoromethyl)phenol

: 180134-15-0
2,4-Bis(trifluoromethyl)-6-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / KOH / 1.) MeOH, 2.) THF, room temp., overnight; reflux, 3 h

2: 84.2 percent / n-BuLi / diethyl ether / 2 h / Ambient temperature

With potassium hydroxide; n-butyllithium; In diethyl ether;
DOI:10.1016/0022-1139(96)03418-5