[4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

Base Information

• Chemical Name: [4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine
• CAS No.: 1338597-08-2
• Molecular Formula: C₂₄H₁₈BrN₅S
• Molecular Weight: 488.41
• Mol file: 1338597-08-2.mol

Synonyms:[4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

Chemical Property of [4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine

There total 5 articles about [4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

C18H13BrN2S (1338597-05-9) + Phenyl azide (622-37-7) → [4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine (1338597-08-2)

Guidance literature:

C₁₈H₁₃BrN₂S; With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 0.25h;

Phenyl azide; In water; tert-butyl alcohol; at 20 ℃; for 24h;

DOI:10.1002/jhet.638

Reference yield:

2-bromo-1-(4-bromophenyl)-2-phenylethanone (24567-06-4) → [4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine (1338597-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: ethanol / 8 h / Reflux

2.1: potassium carbonate / toluene / 8 h / 110 °C / Inert atmosphere

3.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.25 h / 20 °C

3.2: 24 h / 20 °C

With copper(ll) sulfate pentahydrate; potassium carbonate; sodium L-ascorbate; In ethanol; water; toluene; tert-butyl alcohol;

DOI:10.1002/jhet.638

Reference yield:

1-(4-bromophenyl)-2-phenyl-ethan-1-one (2001-29-8) → [4-(4-bromophenyl)-5-phenylthiazol-2-yl](1-phenyl-1H-[1,2,3]triazol-4-yl)methylamine (1338597-08-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: bromine; acetic acid / chloroform / 20 °C

2.1: ethanol / 8 h / Reflux

3.1: potassium carbonate / toluene / 8 h / 110 °C / Inert atmosphere

4.1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 0.25 h / 20 °C

4.2: 24 h / 20 °C

With copper(ll) sulfate pentahydrate; bromine; potassium carbonate; acetic acid; sodium L-ascorbate; In ethanol; chloroform; water; toluene; tert-butyl alcohol;

DOI:10.1002/jhet.638

upstream raw materials:

C₁₈H₁₃BrN₂S

Phenyl azide

2-bromo-1-(4-bromophenyl)-2-phenylethanone

1-(4-bromophenyl)-2-phenyl-ethan-1-one