2001-29-8

Basic information

• Product Name: 4'-Bromo-2-phenylacetophenone
• Synonyms: 1-(4-BROMOPHENYL)-2-PHENYLETHANONE;4-bromodeoxybenzoin;2-CHLOROBENZYL4-CHLOROPHENYLKETONE;benzyl 4-brornophenyl ketone;Benzyl 4-bromophenyl ketone 97%;DEOXY-4-BROMOBENZOIN;BENZYL 4-BROMOPHENYL KETONE;4-BROMODESOXY BENZOIN
• CAS NO: 2001-29-8
• Molecular Formula: C₁₄H₁₁BrO
• Molecular Weight: 275.14
• EINECS: -0
• Product Categories: Aromatic Ketones (substituted);C13 to C14;Carbonyl Compounds;Ketones
• Mol File: 2001-29-8.mol
• Article Data: 43

Chemical Properties

• Melting Point: 112-116 °C(lit.)
• Boiling Point: 383.2 °C at 760 mmHg
• Flash Point: 84.6 °C
• Appearance: White to pale yellow/Crystalline Powder
• Density: 1.39 g/cm³
• Vapor Pressure: 4.47E-06mmHg at 25°C
• Refractive Index: 1.608
• Storage Temp.: 2-8°C
• BRN: 2211322
• CAS DataBase Reference: 4'-Bromo-2-phenylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-Bromo-2-phenylacetophenone(2001-29-8)
• EPA Substance Registry System: 4'-Bromo-2-phenylacetophenone(2001-29-8)

Safety Data

• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• WGK Germany: 3
• Hazardous Substances Data: 2001-29-8(Hazardous Substances Data)

Usage

Chemical Properties

White topale yellow crystalline powder

InChI:InChI=1/C14H11BrO/c15-13-8-6-12(7-9-13)14(16)10-11-4-2-1-3-5-11/h1-9H,10H2

Upstream product

• 698-67-9 p-bromobenzamide 
• 1589-82-8 phenylmagnesium bromide 
• 108-86-1 bromobenzene 
• 103-80-0 phenylacetyl chloride 
• 4333-76-0 1-(4-bromophenyl)-1-phenylethene 
• 623-00-7 4-bromobenzenecarbonitrile 
• 100-44-7 benzyl chloride 
• 192436-83-2 4-bromo-N-methoxy-N-methylbenzamide 
• 6921-34-2 benzylmagnesium chloride 
• 586-75-4 4-chlorobenzoyl chloride 
• 956215-97-7 1-(4-bromophenyl)-3-phenyl-2,3-ditosyloxypropanone 
• 29425-81-8 (4-bromophenyl)(3-phenyloxiran-2-yl)methanone 
• 7677-24-9 trimethylsilyl cyanide 
• 100-39-0 benzyl bromide 

Downstream Products

• 858446-71-6 1-(4-bromo-phenyl)-3-chloro-2,3-diphenyl-propan-1-one 
• 20498-64-0 1-(4-bromophenyl)-2-phenylethan-1-ol 
• 60694-99-7 1-(4-cyanophenyl)-2-phenylethan-1-one 
• 24567-06-4 2-bromo-1-(4-bromophenyl)-2-phenylethanone 
• 31462-14-3 1-(4-Bromo-phenyl)-2-{[2-(4-bromo-phenyl)-2-oxo-1-phenyl-eth-(E)-ylidene]-hydrazono}-2-phenyl-ethanone 
• 3493-17-2 1-(4-bromophenyl)-2-diazo-2-phenylethan-1-one 
• 14310-24-8 1-bromo-4-(2-phenylethyl)benzene 
• 103-29-7 1,1'-(1,2-ethanediyl)bisbenzene 
• 586-76-5 4-Bromobenzoic acid 
• 65-85-0 benzoic acid 
• 945980-25-6 C₁₉H₁₄FNO 
• 13667-11-3 4-(Phenylethinyl)triphenylmethanol 
• 60313-43-1 1-bromo-4-(1-bromo-2-phenylethyl)benzene 
• 60313-13-5 3-(4-bromophenyl)-3,4-dihydro-2H-naphthalen-1-one 

Relevant articles and documents

H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water

An environmentally benign, cost-efficient and practical methodology for the room temperature synthesis of 2-arylacetophenones in water has been discovered. The facile and efficient transformation involves the oxidative radical addition of arylhydrazines with α-aryl vinyl azides in the presence of H2O2 (as a radical initiator) and PEG-800 (as a phase-transfer catalyst). From the viewpoint of green chemistry and organic synthesis, the present protocol is of great significance because of using cheap, non-toxic and readily available starting materials and reagents as well as amenability to gram-scale synthesis, which provides an attractive strategy to access 2-arylacetophenones.

Visible-Light-Promoted [3 + 2] Cycloaddition of 2H-Azirines with Quinones: Access to Substituted Benzo[f]isoindole-4,9-diones

A visible-light-promoteded [3 + 2] cycloaddition reaction of 2H-azirines with quinones has been developed under mild reaction conditions. The reaction provides a general and efficient strategy for the synthesis of the benzo[f]isoindole-4,9-diones scaffold

Ruthenium(II)-Catalyzed Cross-Coupling of Benzoyl Formic Acids with Toluenes: Synthesis of 2-Phenylacetophenones

Herein, we report a direct method to synthesize 2-phenylacetophenone through a ruthenium(II)-catalyzed cross-coupling reaction between acyl and benzyl radical. The various derivatives of 2-phenylacetophenone were prepared easily in moderate to good yields. These reactions provide a straightforward pathway to synthesize a variety of ketones bearing various functional groups.