(4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

Base Information

Chemical Name:(4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester
CAS No.:1415824-80-4
Molecular Formula:C₂₆H₂₄N₄O₃
Molecular Weight:440.502
Hs Code.:

Synonyms:(4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

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Chemical Property of (4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

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Technology Process of (4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

There total 2 articles about (4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1415824-79-1
(4-(6-amino-5-chloro-pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

: 51067-38-0
4-phenoxyphenylboronic acid

: 1415824-80-4
(4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

Guidance literature:: With potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; water; at 150 ℃; for 3h; microwave irradiation; Inert atmosphere;

Reference yield:

: 5438-70-0
ethyl (4-amino-3,5-dibromophenyl)acetate

: 1415824-80-4
(4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / butan-1-ol / 192 h / 115 °C / Inert atmosphere

2: potassium carbonate / palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / 1,4-dioxane; water / 3 h / 150 °C / microwave irradiation; Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; In 1,4-dioxane; water; butan-1-ol; 2: Suzuki Coupling;

Reference yield: 100.0%

: 1415824-80-4
(4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester

: 1415824-81-5
(4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid

Guidance literature:: (4-(6-amino-5-(4-phenoxyphenyl)pyrimidin-4-ylamino)phenyl)acetic acid ethyl ester; With water; sodium hydroxide; In 1,4-dioxane; at 20 ℃; for 1.5h;

With hydrogenchloride; In water;