methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

Base Information

Chemical Name:methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride
CAS No.:1092794-07-4
Molecular Formula:C₁₂H₁₅NO₂*ClH
Molecular Weight:241.718
Hs Code.:

Synonyms:methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

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Chemical Property of methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

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Technology Process of methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

There total 2 articles about methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092794-06-3
1-(2-cyanophenyl)cyclopropanecarboxylic acid methyl ester

: 1092794-07-4
methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 3h; under 1520.1 Torr;

Reference yield:

: 20921-96-4
methyl 2-(2-cyanophenyl)acetate

: 1092794-07-4
methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; tetrabutylammomium bromide / water; toluene / 1 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethanol / 3 h / 20 °C / 1520.1 Torr

With palladium 10% on activated carbon; tetrabutylammomium bromide; hydrogen; sodium hydroxide; In ethanol; water; toluene;

Reference yield:

: 1092794-07-4
methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

: 3-(2,6-dichlorophenyl)-4-imino-7-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one dihydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydroxide / methanol; water / 0.5 h / 20 °C

2: sulfuric acid; potassium nitrate / 0.25 h / 20 °C

3: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / Reflux

4: sodium cyanoborohydride; acetic acid / methanol; water / 15 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / ethanol / 15 h / 20 °C / 760.05 Torr

6: toluene-4-sulfonic acid / butan-1-ol / 0.25 h / 90 °C

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; potassium nitrate; In tetrahydrofuran; methanol; ethanol; water; butan-1-ol;