1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester

Base Information

• Chemical Name: 1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester
• CAS No.: 1092794-06-3
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• Hs Code.: 2926909090
• Mol file: 1092794-06-3.mol

Synonyms:1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester;methyl 1-(2-cyanophenyl)cyclopropanecarboxylate

Chemical Property of 1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester

Chemical Property:

• PSA: 50.09000
• LogP: 1.76288

Purity/Quality:

Methyl1-(2-Cyanophenyl)cyclopropanecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester

There total 4 articles about 1-(2-Cyano-phenyl)-cyclopropanecarboxylic acid Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl 2-(2-cyanophenyl)acetate (20921-96-4) + ethylene dibromide (106-93-4) → 1-(2-cyanophenyl)cyclopropanecarboxylic acid methyl ester (1092794-06-3)

Guidance literature:

With tetrabutylammomium bromide; sodium hydroxide; In water; toluene; at 15 - 30 ℃; for 1h;

Reference yield:

2-(2-cyanophenyl)acetic acid (18698-99-2) → 1-(2-cyanophenyl)cyclopropanecarboxylic acid methyl ester (1092794-06-3)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; methanol / 2 h / 15 - 30 °C

2: tetrabutylammomium bromide; sodium hydroxide / water; toluene / 1 h / 15 - 30 °C

With tetrabutylammomium bromide; sodium hydroxide; In tetrahydrofuran; methanol; water; toluene;

Reference yield:

o-iodophenylacetic acid (18698-96-9) → 1-(2-cyanophenyl)cyclopropanecarboxylic acid methyl ester (1092794-06-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: thionyl chloride / 1 h / 60 °C

2.1: N,N-dimethyl-formamide / 5 h / 130 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.33 h / 0 - 20 °C / Inert atmosphere

3.2: 1.5 h / 0 - 20 °C

With thionyl chloride; sodium hydride; In N,N-dimethyl-formamide;

upstream raw materials:

methyl 2-(2-cyanophenyl)acetate

ethylene dibromide

2-(2-cyanophenyl)acetic acid

o-iodophenylacetic acid

Downstream raw materials:

methyl 1-[2-(aminomethyl)phenyl]cyclopropanecarboxylate monohydrochloride

3-(2,6-dichlorophenyl)-4-imino-7-[(2'-methyl-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-isoquinolin]-7'-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one dihydrochloride

7’-nitro-2’,3’-dihydro-1’H-spiro[cyclopropane-1,4’-isoquinoline]

tert-butyl 7′-amino-1′H-spiro[cyclopropane-1,4′-isoquinoline]-2′(3′H)-carboxylate

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