Technology Process of (-)-phenyl (2R,3R)-4-benzyloxy-3-hydroxy-2-methylbutanoate
There total 4 articles about (-)-phenyl (2R,3R)-4-benzyloxy-3-hydroxy-2-methylbutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-benzyloxy-2-methyl-1-phenylbutane-1,3-dione;
With
formic acid; (R,R)-ruthenium; triethylamine;
In
dichloromethane;
Heating;
With
bis-trimethylsilanyl peroxide; C6H10(NHSO2Tol)2; tin(IV) chloride;
In
dichloromethane;
at 20 ℃;
With
acetic acid;
In
tetrahydrofuran; water;
for 24h;
DOI:10.1016/j.tetlet.2003.09.192
- Guidance literature:
-
(-)-(2R,3R)-4-benzyloxy-3-hydroxy-2-methyl-1-phenyl-butan-1-one;
With
bis-trimethylsilanyl peroxide; rac. trans-N,N'-bis(p-toluenesulfonyl)cylohexan-1,2-diamine; tin(IV) chloride;
4 A molecular sieve;
In
dichloromethane;
at 20 ℃;
for 12h;
With
acetic acid;
In
tetrahydrofuran; water;
at 20 ℃;
for 18h;
DOI:10.1021/jo035068m
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: lithium diisopropylamide / tetrahydrofuran / 1 h / -78 °C
1.2: 72 percent / tetrahydrofuran / 1.75 h / -78 - 20 °C
2.1: (R,R)-ruthenium complex; Et3N; HCO2H / CH2Cl2 / 16 h / 20 °C
3.1: bis(trimethylsilylperoxide); rac. trans-N,N'-bis(p-toluenesulfonyl)cylohexan-1,2-diamine; SnCl4 / molecular sieves 4 Angstroem / CH2Cl2 / 12 h / 20 °C
3.2: acetic acid / tetrahydrofuran; H2O / 18 h / 20 °C
With
formic acid; bis-trimethylsilanyl peroxide; rac. trans-N,N'-bis(p-toluenesulfonyl)cylohexan-1,2-diamine; (R,R)-ruthenium; tin(IV) chloride; triethylamine; lithium diisopropyl amide;
4 A molecular sieve;
In
tetrahydrofuran; dichloromethane;
3.1: Baeyer-Villiger oxidation;
DOI:10.1021/jo035068m
