4',7-di-O-methyl-puerarin

Base Information

• Chemical Name: 4',7-di-O-methyl-puerarin
• CAS No.: 69655-50-1
• Molecular Formula: C₂₃H₂₄O₉
• Molecular Weight: 444.438
• Mol file: 69655-50-1.mol

Synonyms:4',7-di-O-methyl-puerarin

Chemical Property of 4',7-di-O-methyl-puerarin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4',7-di-O-methyl-puerarin

There total 4 articles about 4',7-di-O-methyl-puerarin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-2-{2-acetoxy-6-methoxy-3-[(E)-3-(4-methoxy-phenyl)-acryloyl]-phenyl}-6-acetoxymethyl-tetrahydro-pyran-3-yl ester (69667-95-4) → 4',7-di-O-methyl-puerarin (69655-50-1)

Guidance literature:

Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-2-{2-acetoxy-6-methoxy-3-[(E)-3-(4-methoxy-phenyl)-acryloyl]-phenyl}-6-acetoxymethyl-tetrahydro-pyran-3-yl ester; With thallium(III) nitrate; trimethyl orthoformate; In methanol;

With hydrogenchloride; In methanol; Heating;

DOI:10.1016/S0040-4039(03)01715-5

Reference yield: 46.0%

puerarin (3681-99-0) + methyl iodide (74-88-4) → 4',7-di-O-methyl-puerarin (69655-50-1)

Guidance literature:

puerarin; With potassium tert-butylate; In N,N-dimethyl-formamide; Inert atmosphere;

methyl iodide; In N,N-dimethyl-formamide; for 6h; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.06.077

Reference yield:

→ 4',7-di-O-methyl-puerarin (69655-50-1)

Guidance literature:

3, Cyclis. (oxidat.Umlagerung);

upstream raw materials:

Acetic acid (2S,3S,4R,5R,6R)-4,5-diacetoxy-2-{2-acetoxy-6-methoxy-3-[(E)-3-(4-methoxy-phenyl)-acryloyl]-phenyl}-6-acetoxymethyl-tetrahydro-pyran-3-yl ester

puerarin

methyl iodide

Downstream raw materials:

puerarin

Refernces

• 1、 Lee, David Y. W.,Zhang, Wu-Yan,Karnati, Vishnu Vardhan R.. "Total synthesis of puerarin, an isoflavone C-glycoside". . p. 6857 - 6859. Retrieved 2007/10/03.