2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol

Base Information

Chemical Name:2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol
CAS No.:524712-12-7
Molecular Formula:C₂₀H₂₀BrNO₃
Molecular Weight:402.288
Hs Code.:

Synonyms:2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol

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Chemical Property of 2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol

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Technology Process of 2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol

There total 8 articles about 2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 2-(2-methyl-1,3-dioxolan-2-yl)ethylmagnesium bromide

: 524712-12-7
2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;
DOI:10.1021/ja021380m

Reference yield:

: 88207-45-8
2-(2'-bromophenyl)-1H-indole

: 524712-12-7
2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / NaNO₂ / acetic acid / 3 h / 20 °C

2: 94 percent / Na₂S₂O₄; NaOH / ethanol / 24 h / Heating

3: 98 percent / PbO₂ / benzene / 24 h / Heating

4: 56 percent / aq. HCl / toluene / 12 h / 20 °C

5: 88 percent / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium dithionite; lead dioxide; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid; toluene; benzene;
DOI:10.1021/ja021380m

Reference yield:

: 2142-69-0
2-bromophenyl methyl ketone

: 524712-12-7
2-(2-bromophenyl)-3-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-3H-indol-3-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 78 percent / polyphosphoric acid / 4 h / 100 - 110 °C

2: 97 percent / NaNO₂ / acetic acid / 3 h / 20 °C

3: 94 percent / Na₂S₂O₄; NaOH / ethanol / 24 h / Heating

4: 98 percent / PbO₂ / benzene / 24 h / Heating

5: 56 percent / aq. HCl / toluene / 12 h / 20 °C

6: 88 percent / tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium dithionite; PPA; lead dioxide; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid; toluene; benzene; 1: Fischer indole synthesis;
DOI:10.1021/ja021380m