1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate

Base Information

• Chemical Name: 1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate
• CAS No.: 860302-53-0
• Molecular Formula: C₂₂H₂₇N₅O₂
• Molecular Weight: 393.489

Synonyms:1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate

Chemical Property of 1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate

Chemical Property:

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Technology Process of 1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate

There total 1 articles about 1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3-Benzotriazole (95-14-7,27556-51-0) + benzaldehyde (100-52-7) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate (860302-53-0)

Guidance literature:

In toluene; for 18h; Heating;

DOI:10.1016/j.bmcl.2006.05.051

Reference yield:

1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate (860302-53-0) + (2-chlorobenzyl)zinc(II) chloride (312624-11-6) → tert-butyl 4-[2-(2-chlorophenyl)-1-phenylethyl]piperazine-1-carboxylate (860302-57-4)

Guidance literature:

In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

1-tert-butyl 4-[1H-1,2,3-benzotriazol-1-yl (phenyl) methyl]piperazine-1-carboxylate (860302-53-0) + Grignard reagent from 2-methoxybenzyl chloride (480438-46-8) → 1-[2-(2-methoxy-phenyl)-1-phenyl-ethyl]-piperazine (888406-95-9)

Guidance literature:

In tetrahydrofuran; toluene; at -70 - 0 ℃; for 0.75h;

upstream raw materials:

1,2,3-Benzotriazole

benzaldehyde

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

4-(1,3-diphenyl-propyl)-piperazine-1-carboxylic acid tert-butyl ester

4-(2-naphthalen-1-yl-1-phenyl-ethyl)-piperazine-1-carboxylic acid tert-butyl ester

4-[2-(2,3-dichloro-phenyl)-1-phenyl-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

4-[2-(2,4-dichloro-phenyl)-1-phenyl-ethyl]-piperazine-1-carboxylic acid tert-butyl ester

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