(S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

Base Information

Chemical Name:(S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate
CAS No.:1352937-77-9
Molecular Formula:C₂₂H₁₉ClF₃N₅O₄S
Molecular Weight:541.938
Hs Code.:

Synonyms:(S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

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Chemical Property of (S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

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Technology Process of (S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

There total 11 articles about (S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1300746-10-4
2-((4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

: 1352937-77-9
(S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

Guidance literature:: With dmap; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 1300746-10-4
2-((4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

: 1352937-77-9
(S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3.5h;

Reference yield:

: 6705-03-9
2-Amino-5-methoxybenzoic acid

: 1352937-77-9
(S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 11 steps

1.1: 18 h / 140 °C / Inert atmosphere

2.1: toluene; tetrahydrofuran; diethyl ether / 3 h / 0 - 20 °C / Inert atmosphere

3.1: dichloromethane / 2 h / 60 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 18 h / 80 °C / Inert atmosphere

5.1: tetraphosphorus decasulfide; sodium carbonate / 1,2-dichloro-ethane / 5 h / 65 °C

6.1: hydrazine hydrate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

6.2: 1 h / 0 - 20 °C / Inert atmosphere

7.1: acetic acid / tetrahydrofuran / 18 h / 0 - 20 °C / Inert atmosphere

8.1: sodium hydroxide / water; tetrahydrofuran / 4 h / 20 °C

9.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

9.2: 18 h / 20 °C / Inert atmosphere

10.1: boron tribromide / dichloromethane / 4 h / -78 - 20 °C / Inert atmosphere

11.1: dmap / dichloromethane / 18 h / 20 °C / Inert atmosphere

With dmap; tetraphosphorus decasulfide; boron tribromide; sodium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane; toluene;