(S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Base Information

Chemical Name:(S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide
CAS No.:1352937-21-3
Molecular Formula:C₂₈H₂₆ClN₅O₂
Molecular Weight:500
Hs Code.:

Synonyms:(S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

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Chemical Property of (S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

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Technology Process of (S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

There total 3 articles about (S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352937-77-9
(S)-6-(4-chlorophenyl)-4-(2-(ethylamino)-2-oxoethyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl trifluoromethanesulfonate

: 10365-98-7,1107579-37-2
3-methoxyphenylboronic acid

: 1352937-21-3
(S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Guidance literature:: With potassium carbonate; bis-triphenylphosphine-palladium(II) chloride; In ethanol; toluene; at 120 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1260907-17-2
2-[(4S)-6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4] benzodiazepin-4-yl]-N-ethylacetamide

: 1352937-21-3
(S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: boron tribromide / dichloromethane / 3.08 h / -78 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 20 °C

3: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol / 0.33 h / 120 °C / Microwave irradiation

With boron tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; toluene;

Reference yield:

: 1300746-10-4
2-((4S)-6-(4-chlorophenyl)-8-hydroxy-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

: 1352937-21-3
(S)-2-(6-(4-chlorophenyl)-8-(3-methoxyphenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-4-yl)-N-ethylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3.5 h / 20 °C

2: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / toluene; ethanol / 0.33 h / 120 °C / Microwave irradiation

With potassium carbonate; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; toluene;