4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide

Base Information

Chemical Name:4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide
CAS No.:1424279-76-4
Molecular Formula:C₂₀H₁₆Cl₂F₃N₃O₂S
Molecular Weight:490.333
Hs Code.:

Synonyms:4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide

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Chemical Property of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide

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Technology Process of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide

There total 7 articles about 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1424279-75-3
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

: 1424279-76-4
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide

Guidance literature:: With iron; acetic acid; In isopropyl alcohol; at 70 ℃; for 3h;

Reference yield:

: methyl 4-formyl-2-nitro benzoate

: 1424279-76-4
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium acetate; hydroxylamine hydrochloride / isopropyl alcohol; water / 2 h / 20 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

2.2: 16 h / 20 °C

3.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

4.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere

6.1: iron; acetic acid / isopropyl alcohol / 3 h / 70 °C

With N-chloro-succinimide; oxalyl dichloride; hydroxylamine hydrochloride; water; sodium acetate; iron; acetic acid; triethylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1424279-71-9
methyl 4-hydroxyiminomethyl-2-nitrobenzoate

: 1424279-76-4
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-amino-N-(thietan-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere

5.1: iron; acetic acid / isopropyl alcohol / 3 h / 70 °C

With N-chloro-succinimide; oxalyl dichloride; water; iron; acetic acid; triethylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;