4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

Base Information

Chemical Name:4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide
CAS No.:1424279-75-3
Molecular Formula:C₂₀H₁₄Cl₂F₃N₃O₄S
Molecular Weight:520.316
Hs Code.:

Synonyms:4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

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Chemical Property of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

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Technology Process of 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

There total 6 articles about 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₈Cl₃F₃N₂O₄

: 128861-76-7
3-Thiacyclobutylamin

: 1424279-75-3
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

Guidance literature:: With triethylamine; In tetrahydrofuran; for 16h; Inert atmosphere;

Reference yield:

: 1424279-71-9
methyl 4-hydroxyiminomethyl-2-nitrobenzoate

: 1424279-75-3
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

1.2: 16 h / 20 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

4.1: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere

With N-chloro-succinimide; oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1426054-32-1
methyl 4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-3-yl]-2-nitrobenzoate

: 1424279-75-3
4-[5-(3,5-dichlorophenyl)-5-trifluoromethyl-4H-isoxazol-3-yl]-2-nitro-N-(thietan-3-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: water; lithium hydroxide / tetrahydrofuran / 1 h / 20 °C

2: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 20 °C / Inert atmosphere

3: triethylamine / tetrahydrofuran / 16 h / Inert atmosphere

With oxalyl dichloride; water; triethylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; dichloromethane;