(1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide

Base Information

Chemical Name:(1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide
CAS No.:191278-17-8
Molecular Formula:C₁₇H₂₂O
Molecular Weight:242.361
Hs Code.:

Synonyms:(1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide

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Chemical Property of (1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide

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Technology Process of (1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide

There total 5 articles about (1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 104197-81-1
(1S*,8R*,9R*,10R*)-8-phenyl-1-decalol

: 191278-17-8
(1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / pyridine / 4 h / Heating

2: 35 percent / diethyl cyanophosphate, Et₃N / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 5 h

3: 89 percent / KOH / ethanol / 7 h / Heating

4: 91 percent / Jones reagent / acetone / 1 h / 0 °C

5: 1.) KOt-Bu / 1.) Et₂O, room temperature, 1 h, 2.) Et₂O, CH₂Cl₂, room temperature, 8 h

6: 1.) NBS, 2.) KOH / 1.) DME, H₂O, room temperature, 3 h, 2.) MeOH, H₂O, room temperature, 10 min

With potassium hydroxide; N-Bromosuccinimide; jones reagent; diethyl cyanophosphonate; potassium tert-butylate; triethylamine; In pyridine; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo970082i

Reference yield:

: (1S*,8R*,9R*,10R*)-8-phenyl-1-decalyl hydrogen phthalate

: 191278-17-8
(1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide

Guidance literature:: Multi-step reaction with 5 steps

1: 35 percent / diethyl cyanophosphate, Et₃N / dimethylformamide / 1.) 0 deg C, 30 min, 2.) room temperature, 5 h

2: 89 percent / KOH / ethanol / 7 h / Heating

3: 91 percent / Jones reagent / acetone / 1 h / 0 °C

4: 1.) KOt-Bu / 1.) Et₂O, room temperature, 1 h, 2.) Et₂O, CH₂Cl₂, room temperature, 8 h

5: 1.) NBS, 2.) KOH / 1.) DME, H₂O, room temperature, 3 h, 2.) MeOH, H₂O, room temperature, 10 min

With potassium hydroxide; N-Bromosuccinimide; jones reagent; diethyl cyanophosphonate; potassium tert-butylate; triethylamine; In ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo970082i

Reference yield:

: 191278-23-6
(1S,8R,9R,10R)-8-phenyl-1-decalol

: 191278-17-8
(1S,8R,9R,10R)-8-phenyl-1-methylenedecalin oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / Jones reagent / acetone / 1 h / 0 °C

2: 1.) KOt-Bu / 1.) Et₂O, room temperature, 1 h, 2.) Et₂O, CH₂Cl₂, room temperature, 8 h

3: 1.) NBS, 2.) KOH / 1.) DME, H₂O, room temperature, 3 h, 2.) MeOH, H₂O, room temperature, 10 min

With potassium hydroxide; N-Bromosuccinimide; jones reagent; potassium tert-butylate; In acetone;
DOI:10.1021/jo970082i