2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol

Base Information

• Chemical Name: 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol
• CAS No.: 206071-84-3
• Molecular Formula: C₂₀H₁₉BrO₅
• Molecular Weight: 419.272
• Mol file: 206071-84-3.mol

Synonyms:2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol

Chemical Property of 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol

There total 5 articles about 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium iodide (113542-06-6) → 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol (206071-84-3)

Guidance literature:

With sodium hydroxide; In methanol; Heating;

DOI:10.1016/S0040-4039(98)00167-1

Reference yield:

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxyisoquinoline (51449-10-6) → 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol (206071-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / acetone / 20 °C

2: 45 percent / NaOH / methanol / Heating

With sodium hydroxide; In methanol; acetone; 1: Alkylation / 2: Ring cleavage;

DOI:10.1016/S0040-4020(00)00551-2

Reference yield:

Papaverine (58-74-2) → 2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol (206071-84-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / Br₂ / acetic acid; H₂O / 3.5 h / 20 °C

2: 92 percent / acetone / 20 °C

3: 45 percent / NaOH / methanol / Heating

With sodium hydroxide; bromine; In methanol; water; acetic acid; acetone; 1: Bromination / 2: Alkylation / 3: Ring cleavage;

DOI:10.1016/S0040-4020(00)00551-2

upstream raw materials:

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium iodide

Papaverine

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxyisoquinoline

N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide

Downstream raw materials:

2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-1,4-naphthalenedione

2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione