Isoquinolinium,1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-,iodide

Base Information

• Chemical Name: Isoquinolinium,1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-,iodide
• CAS No.: 113542-06-6
• Molecular Formula: C21H23BrNO4.I
• Molecular Weight: 560.226
• Mol file: 113542-06-6.mol

Synonyms:Isoquinolinium,1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-,iodide

Chemical Property of Isoquinolinium,1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-,iodide

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isoquinolinium,1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-,iodide

There total 5 articles about Isoquinolinium,1-[(2-bromo-4,5-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-,iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxyisoquinoline (51449-10-6) + methyl iodide (74-88-4) → 1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium iodide (113542-06-6)

Guidance literature:

at 80 ℃; for 2h;

DOI:10.1021/ol006213a

Reference yield:

Papaverine (58-74-2) → 1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium iodide (113542-06-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / Br₂ / acetic acid; H₂O / 3.5 h / 20 °C

2: 92 percent / acetone / 20 °C

With bromine; In water; acetic acid; acetone; 1: Bromination / 2: Alkylation;

DOI:10.1016/S0040-4020(00)00551-2

Reference yield:

N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide (139-76-4) → 1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxy-2-methylisoquinolinium iodide (113542-06-6)

Guidance literature:

Multi-step reaction with 3 steps

1: POCl₃ / acetonitrile

2: bromine / acetic acid

3: acetone

With bromine; trichlorophosphate; In acetic acid; acetone; acetonitrile;

DOI:10.1016/S0040-4039(98)00167-1

upstream raw materials:

1-(2'-bromo-4',5'-dimethoxybenzyl)-6,7-dimethoxyisoquinoline

methyl iodide

Papaverine

N-(3,4-dimethoxyphenethyl)-2-(3,4-dimethoxyphenyl)acetamide

Downstream raw materials:

2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1-naphthol

1-(2-bromo-4,5-dimethoxybenzyl)-2-methyl-6,7-dimethoxy-1,2-dihydroisoquinoline

2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-1,4-naphthalenedione

2-(2'-bromo-4',5'-dimethoxyphenyl)-6,7-dimethoxy-1,4-dihydro-3-hydroxy-1,4-naphthalenedione