1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene

Base Information

• Chemical Name: 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene
• CAS No.: 284031-80-7
• Molecular Formula: C₉H₈ClF₃S
• Molecular Weight: 240.677
• Mol file: 284031-80-7.mol

Synonyms:1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene

Chemical Property of 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene

There total 3 articles about 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1,1,1-trifluoro-2,2-dichloroethane (306-83-2) + para-thiocresol (106-45-6) → (2,2,2-trifluoroethyl) (4-methylphenyl) sulfide (62158-92-3) + 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene (284031-80-7)

Guidance literature:

With copper; diethylamine; triethylamine; at 75 ℃; for 24h; Concentration; Temperature; Inert atmosphere; Sealed tube;

DOI:10.1021/ol302962p

Reference yield: 73.0%

1,1,1-trifluoro-2-bromo-2-chloroethane (151-67-7) + para-thiocresol (106-45-6) → 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene (284031-80-7)

Guidance literature:

para-thiocresol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 0 ℃; for 0.166667h;

1,1,1-trifluoro-2-bromo-2-chloroethane; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 4h;

DOI:10.1248/cpb.48.683

Reference yield: 54.0%

1,1,1-trifluoro-2,2-dichloroethane (306-83-2) + para-thiocresol (106-45-6) → di(p-tolyl) disulfide (103-19-5) + (2,2,2-trifluoroethyl) (4-methylphenyl) sulfide (62158-92-3) + C16H15F3S2 + 1-[(1-chloro-2,2,2-trifluoroethyl)sulfanyl]-4-methylbenzene (284031-80-7)

Guidance literature:

With sodium dithionite; triethylamine; In dimethyl sulfoxide; at 70 ℃; for 3h; Reagent/catalyst; Solvent; Temperature; Mechanism; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.jfluchem.2014.10.006

upstream raw materials:

1,1,1-trifluoro-2-bromo-2-chloroethane

para-thiocresol

1,1,1-trifluoro-2,2-dichloroethane

Downstream raw materials:

di(p-tolyl) disulfide

(2,2,2-trifluoroethyl) (4-methylphenyl) sulfide

1,1,1-trifluoro-2-(4-methylbenzenesulfonyl)ethane