6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Base Information

Chemical Name:6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester
CAS No.:1456626-20-2
Molecular Formula:C₃₆H₆₃N₃O₁₀
Molecular Weight:697.91
Hs Code.:

6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Synonyms:6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Suppliers and Price of 6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

There total 8 articles about 6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1456626-19-9
6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-(methoxycarbonyl)-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

: 1456626-20-2
6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Guidance literature:: With water; sodium hydroxide; In isopropyl alcohol; at 20 ℃; for 5.5h;

Reference yield:

: 66185-74-8
(1r,4r)‐4‐(hydroxymethyl)cyclohexane‐1‐carboxylic acid

: 1456626-20-2
6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfuric acid / 4 h / Reflux

2.1: triethylamine / tetrahydrofuran / 2.17 h / 0 - 20 °C

3.1: sodium iodide / acetone; diethyl ether / 72.5 h / 20 °C / Reflux

4.1: sodium nitrite; 3,5-dihydroxyphenol / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

5.1: ethanol / 1.5 h / 60 - 80 °C

5.2: 6 h / 80 °C

6.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

7.1: potassium carbonate; sodium sulfate / acetonitrile; ethyl acetate / 1 h / 80 °C

8.1: water; sodium hydroxide / isopropyl alcohol / 5.5 h / 20 °C

With 3,5-dihydroxyphenol; sulfuric acid; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium sulfate; triethylamine; sodium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 1112178-70-7
(1R,4R)-4-[(methylsulfonyloxy)methyl]cyclohexanecarboxylic acid methyl ester

: 1456626-20-2
6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium iodide / acetone; diethyl ether / 72.5 h / 20 °C / Reflux

2.1: sodium nitrite; 3,5-dihydroxyphenol / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

3.1: ethanol / 1.5 h / 60 - 80 °C

3.2: 6 h / 80 °C

4.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

5.1: potassium carbonate; sodium sulfate / acetonitrile; ethyl acetate / 1 h / 80 °C

6.1: water; sodium hydroxide / isopropyl alcohol / 5.5 h / 20 °C

With 3,5-dihydroxyphenol; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium sulfate; sodium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; acetonitrile;