6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

Base Information

Chemical Name:6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester
CAS No.:1456626-21-3
Molecular Formula:C₄₀H₆₆N₄O₁₂
Molecular Weight:794.984
Hs Code.:

6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

Synonyms:6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

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Chemical Property of 6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

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Technology Process of 6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

There total 9 articles about 6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1456626-20-2
6-[bis[2-(1,1-dimethylethoxy)-2-oxoethyl]amino]-6-[(1R,4R)-4-carboxy-cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis(1,1-dimethylethyl)ester

: 1456626-21-3
6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 49h;

Reference yield:

: 1112178-70-7
(1R,4R)-4-[(methylsulfonyloxy)methyl]cyclohexanecarboxylic acid methyl ester

: 1456626-21-3
6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium iodide / acetone; diethyl ether / 72.5 h / 20 °C / Reflux

2.1: sodium nitrite; 3,5-dihydroxyphenol / dimethyl sulfoxide / 48 h / 20 °C / Inert atmosphere

3.1: ethanol / 1.5 h / 60 - 80 °C

3.2: 6 h / 80 °C

4.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

5.1: potassium carbonate; sodium sulfate / acetonitrile; ethyl acetate / 1 h / 80 °C

6.1: water; sodium hydroxide / isopropyl alcohol / 5.5 h / 20 °C

7.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

With 3,5-dihydroxyphenol; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium iodide; sodium hydroxide; sodium nitrite; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetone; acetonitrile;

Reference yield:

: 1456626-16-6
(1R,4R)-4-(nitromethyl)cyclohexanecarboxylic acid methyl ester

: 1456626-21-3
6-[bis[2-[(1,1-dimethyl)ethoxy]-2-oxoethyl]amino]-6-[(1R,4R)-4-[[(2,5-dioxopyrrolidin-1-yl)oxy]carbonyl]cyclohexane-1-yl]tetrahydro-1H-1,4-diazepine-1,4(5H)-diacetic acid bis[(1,1-dimethyl)ethyl] ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethanol / 1.5 h / 60 - 80 °C

1.2: 6 h / 80 °C

2.1: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran; methanol / 11 h / 40 °C

3.1: potassium carbonate; sodium sulfate / acetonitrile; ethyl acetate / 1 h / 80 °C

4.1: water; sodium hydroxide / isopropyl alcohol / 5.5 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 49 h / 0 - 20 °C

With 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium sulfate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; isopropyl alcohol; acetonitrile;