Benzene, 1-(benzyloxy)-4-(2-propynyloxy)- (7CI,8CI)

Base Information

• Chemical Name: Benzene, 1-(benzyloxy)-4-(2-propynyloxy)- (7CI,8CI)
• CAS No.: 6903-14-6
• Molecular Formula: C16H14 O2
• Molecular Weight: 238.286
• Hs Code.: 2909309090
• Mol file: 6903-14-6.mol

Synonyms:Benzene,1-(benzyloxy)-4-(2-propynyloxy)- (7CI,8CI); Benzene,1-(phenylmethoxy)-4-(2-propynyloxy)- (9CI)

Chemical Property of Benzene, 1-(benzyloxy)-4-(2-propynyloxy)- (7CI,8CI)

Chemical Property:

• PSA: 18.46000
• LogP: 3.27760

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1-(benzyloxy)-4-(2-propynyloxy)- (7CI,8CI)

There total 4 articles about Benzene, 1-(benzyloxy)-4-(2-propynyloxy)- (7CI,8CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-Benzyloxyphenol (103-16-2) + propargyl bromide (106-96-7) → 1-(benzyloxy)-4-(prop-2-yn-1-yloxy)benzene (6903-14-6)

Guidance literature:

In acetone; toluene; at 20 ℃;

DOI:10.1021/ol0489898

Reference yield: 87.0%

4-Benzyloxyphenol (103-16-2) + 2-propynyl chloride (624-65-7) → 1-(benzyloxy)-4-(prop-2-yn-1-yloxy)benzene (6903-14-6)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.bmcl.2018.04.012

Reference yield:

benzyl bromide (100-39-0) → 1-(benzyloxy)-4-(prop-2-yn-1-yloxy)benzene (6903-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 10 h / 20 °C / Inert atmosphere

2: potassium carbonate / acetone / 24 h / Inert atmosphere; Reflux

With potassium carbonate; In N,N-dimethyl-formamide; acetone;

upstream raw materials:

4-Benzyloxyphenol

propargyl bromide

2-propynyl chloride

benzyl bromide

Downstream raw materials:

4-(prop-2-yn-1-yloxy)phenol

6-(benzyloxy)chroman-3-one

4-Benzyloxyphenol